Results 41 to 50 of about 12,690 (238)

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Peripherally acting α-adrenoceptor antagonist MK-467 with intramuscular medetomidine and butorphanol in dogs: A prospective, randomised, clinical trial. [PDF]

, 2018
The aim of this study was to investigate the clinical usefulness of MK-467 (vatinoxan; L-659'066) in dogs sedated for diagnostic imaging with medetomidine-butorphanol.
Casoni, D., Honkavaara, J. M., Salla, K. M., Hautajarvi, H. J., Vainio, O. M., Kallio-Kujala, I J, Casoni, Daniela, Honkavaara, J M, Hautajärvi, H J, Salla, K M, Raekallio, M. R., Turunen, H A, Turunen, H. A., Kallio-Kujala, I. J., Raekallio, M R, Vainio, O M   +15 more
core   +2 more sources

Fatalities within seven days after equine standing sedation: A prospective, multicentre study

Equine Veterinary Journal, EarlyView.
Abstract Background Information regarding mortality associated with standing procedures in horses is sparse. Objectives To report data from >12,000 standing sedations. Study Design Confidential, observational, prospective, multicentre, cohort study.
Miguel Gozalo‐Marcilla, José I. Redondo, Polly M. Taylor, Luis Domenech, Javier Doménech, Gordon Mark Johnston, Regula Bettschart‐Wolfensberger   +6 more
wiley   +1 more source

Serum osteocalcin is associated with scintigraphic abnormalities in lame and clinically sound racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background Musculoskeletal injury is a major welfare and economic challenge in racehorses, with stress‐related bone injury contributing to training interruption and catastrophic failure. Advanced imaging modalities can detect early skeletal pathology but remain limited in routine screening environments.
Peter Tually, Dominique Blache, Jack Meadows, Shiphrah Tagore, Paul O'Callaghan, Matilda Hathway, Ian Fulton, Geoffrey Currie   +7 more
wiley   +1 more source

Anti-tumor activity of butorphanol in colorectal cancer via targeting SIGMAR1

Discover Oncology
Colorectal cancer (CRC) stands for a prevailing gastrointestinal neoplasm, concomitant with considerable occurrence and lethality rate. Butorphanol, a synthetic opioid analgesic medication targeting the opiate receptor, has been recently reckoned to ...
Xueqi Hou, Longfei Qu, Yong Xu, Jie Liu, Jianlian Guo   +4 more
doaj   +1 more source

Resident and translocated American black bear movement patterns help identify locations for crossing structures along Interstate 40 in Tennessee and North Carolina

The Journal of Wildlife Management, EarlyView.
Bears selected areas with lower percent slope and higher percent canopy, but movement flow across the landscape was more generalized for translocated bears. Interstate 40 was a barrier to movement, but our models predicted several consistent road segments as having higher than average flow where bears might benefit from crossing structures.
Kristin J. Botzet, Joseph D. Clark, Logan K. Parr   +2 more
wiley   +1 more source

Target-controlled infusions of butorphanol worsen hemodynamics in isoflurane-anesthetized cats

Frontiers in Veterinary Science
IntroductionPartial intravenous anesthesia can be used to reduce the adverse effects of inhalant anesthetics, and opioids are often used in this context in dogs and cats.
Bruno H. Pypendop, Alessia Cenani, Marcela L. Machado, Linda S. Barter   +3 more
doaj   +1 more source

The Regulatory Role and Mechanism of Myoferlin in Mitophagy During Papillary Thyroid Carcinogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Papillary thyroid carcinoma (PTC) is the most prevalent subtype of thyroid cancer; however, the regulatory mechanisms by which mitophagy influences its progression remain inadequately elucidated. This study sought to examine the role of myoferlin (MYOF) in mitophagy and its molecular basis during PTC development. Utilizing three paired PTC and
Wen‐Chao Lyu, Yang‐Shuai Wang, Chun‐Yang Shang, Ming Qi, Tong‐Chang Li, Li‐Xin Lian, Hai‐Quan Qiao   +6 more
wiley   +1 more source

SEDATIVE AND ANALGESIC EFFECTS OF DETOMIDINE WITH AND WITHOUT BUTORPHANOL IN DONKEYS [PDF]

Assiut Veterinary Medical Journal, 1997
Detomidine either 10,20 or 40 ug/kg was administered intravenously alone or in combination with butorphanol in 3 different doses (25,50 or 75 ug/kg) in donkeys. The levels of sedation and analgesia were graded and recorded.
A.H. ATTA, H.M. EL-MAGHRABY
doaj   +1 more source

Alfaxalone-butorphanol versus alfaxalone-morphine combination for immersion anaesthesia in oriental fire-bellied toads (Bombina orientalis) [PDF]

, 2016
Oriental fire-bellied toads (Bombina orientalis) are small semi-aquatic anuran species popular as both pets and laboratory animals. Although they are commonly anaesthetized to undergo clinical and experimental procedures, very little is known about their
D'Ovidio, D, d'Ovidio, Dario, Adami, C, Adami, Chiara, Casoni, Daniela, Casoni, D, Casoni D, d'Ovidio D, Adami C   +8 more
core   +1 more source