Results 111 to 120 of about 11,650 (154)

UK-5099, a mitochondrial pyruvate carrier inhibitor, recovers impaired neutrophil maturation caused by AK2 deficiency in human pluripotent stem cell models

Biochemical and Biophysical Research Communications, 2023
Reticular dysgenesis (RD) is a rare genetic disease caused by gene mutations in the ATP:AMP phosphotransferase, adenylate kinase 2 (AK2). Patients with RD suffer from severe combined immunodeficiency with neutrophil maturation arrest.
Ayako Tanimura, Akira Niwa, Megumú K Saito   +2 more
exaly   +2 more sources

UK-5099 does not inhibit the mitochondrial pyruvate carrier through irreversible adduction to cysteine 54 in MPC2

Free Radical Biology and Medicine, 2023
Oleksandra Prysyazhna, Philip Eaton
exaly   +2 more sources

METTL14-mediated m6A methylation of pri-miR-5099 to facilitate cardiomyocyte pyroptosis in myocardial infarction

Acta Pharmacologica Sinica
Ya-Dong Xue, Guo Jun-Nan
exaly   +2 more sources

Abstract 5099: Anti-tumor effect of DA-4505, a novel AhR antagonist as an immunotherapy in the tumor microenvironment

Cancer Research, 2023
Aryl hydrocarbon receptor(AhR) is a ligand-dependent transcription factor that regulates the activity of innate and adaptive immune cells subsequent to binding of numerous endogenous and exogenous ligands.
D. Cha, Dajeong Kim, Jongho Cho, Chaelim Ryu, Hyeon-U Jeong, Dae Y Lee, Kyu-Hwan Kim, Sunghwam Kim, Jee-Heun Kim, T. Han, Hyounmie Doh   +10 more
semanticscholar   +1 more source

Corporate Bankruptcy Law in China: Principles, Limitations and Options for Reform Natalie Mrockova Oxford: Hart Publishing, 2021 293 pp. £76.50 ISBN 978-1-5099-3244-3

The China Quarterly, 2022
disputes. The author analyses the major cases, focusing on the issues raised, the tribunals’ interpretations and the implications of the rulings. Shen Wei opens each chapter by setting the stage thematically for the detailed discussion that follows ...
Zinian Zhang
semanticscholar   +1 more source

Abstract 5099: Quantification of TGFβ protein levels and digital pathology-based immune phenotyping reveal biomarkers for TGF-β blockade therapy patient selection in NSCLC

Cancer Research, 2022
Introduction TGFβ is an immunoregulatory cytokine that can function as an oncogenic factor to mediate tumorigenesis, metastasis, and immune escape. Recent studies have shown that TGFβ can drive immune-excluded phenotype in tumor microenvironment (TME ...
R. Pomponio, Carrie A. Hendricks, S. Bean, Hong Wang, Sergine Brutus, Charles Biddle-Snead, A. Khosla, Adam Stanford-Moore, C. Hedvat, Qicai Tang, R. Trullo, B. Demers, Rui Wang   +12 more
semanticscholar   +1 more source

Abstract 5099: Large-cell neuroendocrine carcinoma cells of the lung induce a tumor-promoting senescent phenotype in fibroblasts through MMP1 overexpression and TGFβ1

Tumor Biology, 2020
Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA Tumor-associated fibroblasts (TAFs) exhibit an activated/fibrotic phenotype in all subtypes of non-small cell lung cancer.
Marta Gabasa, Rafael Ikemori, M. Arshakyan, E. Radisky, N. Reguard, D. Radisky, J. Alcaraz   +6 more
semanticscholar   +1 more source

Abstract 5099: Notch inhibition as a therapeutic approach to eliminate dormant cancer cells in multiple myeloma

Cancer Research
Multiple myeloma (MM) remains incurable due to disease relapses, thought to stem from the activation of dormant MM cells. Preventing the awakening or eliminating dormant MM cells is crucial to avoiding disease relapse.
H. Sabol, A. Anloague, Japneet Kaur, Sharmin Khan, Bethany C. Paxton, James Smith, Michelle McDonald, Peter I. Croucher, C. L. Barnes, E. Ambrogini, Alison Frontier, F. H. Ebetino, J. Delgado-Calle   +12 more
semanticscholar   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advancement of science
Obesity underlies metabolic dysfunction and contributes to the pathogenesis of various diseases. Obesity associated adipose tissue (AT) inflammation contributes to whole body inflammation vulnerability and metabolic disease development.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jing Cui, Shuhai Lin, Li-jun Di, Li Wang   +9 more
semanticscholar   +1 more source

Abstract 5099: Prevalence of fibroblast growth factor receptor (FGFR) alterations (alts) and programmed death-ligand 1 (PD-L1) expression (exp) in Chinese solid tumor patients (pts)

Cancer Research
Background: PD-L1 expression drives anti-PD(L)-1 treatment decisions across many cancer indications. FGFR inhibitors have been approved for the treatment of metastatic urothelial cancer (UC) and cholangiocarcinoma with FGFR alts. BALVERSA (erdafitinib),
Min Qing, Fei Yang, Xiaowei Chen, Xuesong Lyu, Aodi Wang, Yanfei Yu, Shibu Thomas, Longen Zhou   +7 more
semanticscholar   +1 more source