Results 31 to 40 of about 8,251 (219)

First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study.

Cancer Discovery, 2017
Ulixertinib (BVD-523) is an ERK1/2 kinase inhibitor with potent preclinical activity in BRAF- and RAS-mutant cell lines. In this multicenter phase I trial (NCT01781429), 135 patients were enrolled to an accelerated 3 + 3 dose-escalation cohort and six ...
R. Sullivan, J. Infante, F. Janku, D. Wong, J. Sosman, V. Keedy, M. Patel, G. Shapiro, J. Mier, A. Tolcher, A. Wang-Gillam, M. Sznol, K. Flaherty, E. Buchbinder, R. Carvajal, A. Varghese, M. Lacouture, A. Ribas, S. Patel, G. Decrescenzo, Caroline M. Emery, A. Groover, Saurabh Saha, M. Varterasian, D. Welsch, D. Hyman, Bob T. Li   +26 more
semanticscholar   +1 more source

A Case Series of Neuropsychological Outcome After Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Refractory Obsessive–Compulsive Disorder

, 2021
Neuromodulation: Technology at the Neural Interface, EarlyView.
Tim A. M. Bouwens van der Vlis, Annelien A. Duits   +1 more
wiley   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)

Molecular Cancer Therapeutics, 2017
Aberrant activation of signaling through the RAS–RAF–MEK–ERK (MAPK) pathway is implicated in numerous cancers, making it an attractive therapeutic target.
U. Germann, Brinley F Furey, W. Markland, R. Hoover, A. Aronov, J. Roix, Michael R. Hale, D. Boucher, D. Sorrell, G. Martínez-Botella, M. Fitzgibbon, P. Shapiro, M. Wick, R. Samadani, K. Meshaw, A. Groover, G. Decrescenzo, M. Namchuk, Caroline M. Emery, Saurabh Saha, D. Welsch   +20 more
semanticscholar   +1 more source

Cross-Reactivity Antibody Response after Vaccination with Modified Live and Killed Bovine Viral Diarrhoea Virus (BVD) Vaccines

Vaccines, 2020
Pestivirus A or bovine viral diarrhoea virus (BVDV) type 1 is responsible for cosmopolitan diseases affecting cattle and other ruminants, presenting a wide range of clinical manifestations, with relevant impact on zootechnic production.
E. Sozzi, C. Righi, M. Boldini, M. Bazzucchi, G. Pezzoni, M. Gradassi, S. Petrini, D. Lelli, Giordano Ventura, I. Pierini, A. Moreno, E. Brocchi, A. Lavazza, G. M. De Mia   +13 more
semanticscholar   +1 more source

BVD seroprevalence in the Irish cattle population as the national BVD programme progresses toward eradication

BMC Veterinary Research, 2022
Abstract Background Bovine Viral Diarrhoea Virus (BVDV) infection remains endemic in many countries worldwide. Ireland, in common with several other European counties, commenced an BVDV eradication programme in the last decade, Managing eradication programmes requires careful monitoring of diseases prevalence and ...
Damien Barrett, AnneMarie Clarke, Kate O’Keeffe, Padraig Kellegher, John Comerford, Elizabeth Lane, Andrew W. Byrne   +6 more
openaire   +3 more sources

The Northern Ireland Control Programmes for Infectious Cattle Diseases Not Regulated by the EU

Frontiers in Veterinary Science, 2021
The disease control programmes for Bovine Viral Diarrhoea (BVD), Infectious Bovine Rhinotracheitis (IBR), Johne's Disease (JD), Leptospirosis and Neosporosis are described including the approved diagnostic tools, diagnostic quality systems, and the role ...
Sam Strain, Sharon Verner, Emma Campbell, Jaka Jakob Hodnik, I. M. G. A. Santman-Berends   +4 more
doaj   +1 more source

Factores de riesgo a nivel de establo asociados con el desempeño reproductivo en el sistema de producción de leche a pequeña escala en México

Revista Mexicana de Ciencias Pecuarias, 2019
La rentabilidad de los establos lecheros está fuertemente asociada con el desempeño reproductivo. Por lo tanto, la identificación de factores de riesgo que comprometen este desempeño es primordial para implementar estrategias que mejoren la productividad.
Luis Javier Montiel-Olguín, Eliab Estrada-Cortés, Mario Alfredo Espinosa-Martínez, Miguel Mellado, Josafath Omar Hernández-Vélez, Guillermina Martínez-Trejo, Laura Hérnández-Andrade, Rubén Hernández-Ortíz, Arcelia Alvarado-Islas, Felipe J Ruiz-López, Héctor Raymundo Vera-Avila   +10 more
doaj   +1 more source

Ni target development for the TULIP project [PDF]

EPJ Web of Conferences, 2023
The TULIP project (https://anr.fr/Projet-ANR-18-CE31-0023) aims to produce radioactive ion beams of short-lived neutron-deficient isotopes using fusion-evaporation nuclear reactions in an Isotope Separator On Line (ISOL) system. A Ni target was chosen to
Jardin Pascal, Bosquet Vincent, Damoy Samuel, Frémont Georges, Perocheau Franck, MacCormick Marion   +5 more
doaj   +1 more source

Evidence of bovine viral diarrhea virus in buffaloes (Bubalus bubalis) in Nineveh province [PDF]

Iraqi Journal of Veterinary Sciences
Investigating the sources of Pestivirus, family Flaviviridae, and bovine viral diarrhea virus (BVDV) infections is important in the epidemiology and control efficacy of this disease in large and small ruminants.
Qaes T. Alsarhan, Fanar A. Isihak, Sadam D. Hasan, Osama Z. Abdulla, Wisam S. Hassan   +4 more
doaj   +1 more source