Results 111 to 120 of about 378,041 (365)

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Boehm, Olaf, Bornstein, Stefan R., Grotemeyer, Dirk, Hamann, Lutz, Koch, Alexander, Kurt, Muhammed, Schott, Matthias, Schumann, Ralf R., Schwenke, Carsten, Zacharowski, Kai   +9 more
core   +2 more sources

Cytokine Engineering Approaches for Regenerative Medicine

Advanced Therapeutics, EarlyView.
Engineered cytokines represent a powerful strategy to promote tissue repair and regeneration by precisely modulating immune responses. This review highlights recent advances in cytokine engineering, including strategies to enhance half‐life, improve tissue and cell targeting, and control receptor signaling.
Shiyi Li, Wenhao You, Mikaël M. Martino
wiley   +1 more source

Modified Glucose-Insulin-Potassium Regimen Provides Cardioprotection With Improved Tissue Perfusion in Patients Undergoing Cardiopulmonary Bypass Surgery [PDF]

, 2020
Background Laboratory studies demonstrate glucose-insulin-potassium (GIK) as a potent cardioprotective intervention, but clinical trials have yielded mixed results, likely because of varying formulas and timing of GIK treatment and different clinical ...
Chen, Wensheng, Cui, Qin, Gao, Feng, Li, Jia, Liu, Jincheng, Ma, Xin-Liang, Wan, Yi, Yi, Dinghua, Yu, Shiqiang, Zhang, Yue, Zhao, Bijun, Zhao, Kun, Zhao, Rong   +12 more
core   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Cognitive outcomes after extracranial-intracranial bypass surgery in elderly patients diagnosed with atherosclerotic cerebral steno-occlusive artery disease

Frontiers in Aging Neuroscience
BackgroundThe safety and clinical effectiveness of extracranial–intracranial (EC–IC) bypass surgery in elderly patients with atherosclerotic internal carotid artery and/or middle cerebral artery steno-occlusive (ACMSO) disease remain ambiguous.
Yu Duan, Jian Li, Xin Zhang, Shihong Li, Shihong Li, Qiliang Chai, Yingying Zhang, Guohui Huang, Ziwei Xu, Zhuyu Li, Renling Mao, Dongwei Dai   +11 more
doaj   +1 more source

Measuring and Monitoring Cognition in the Postoperative Period [PDF]

, 2019
It is common for patients of all ages to experience some degree of cognitive disturbance following surgery. In most cases, impairment appears mild and is restricted to the acute post-operative period, resolving steadily and speedily. In a small number of
Newman, S. P., Piggin, L. H.
core   +1 more source

Physics of Selective Targeting of Cancer Cells by Magnetoelectric Nanoparticles: Exploring the Role of Conductivity and Capacitance in Tumor‐Specific Attraction

Advanced Theory and Simulations, EarlyView.
Magnetoelectric nanoparticles exploit cancer cells' electrical vulnerabilities—altered membrane charge and higher capacitance—to achieve tumor‐specific targeting without bioreagents. MATLAB simulations reveal how electromagnetic forces create targeting specificity, while external magnetic fields enhance precision. This may enable wirelessly controlled,
Max Shotbolt, John Bryant, Ping Liang, Sakhrat Khizroev   +3 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Implementation of a graft surveillance programme for infrainuginal vascular bypass surgery [PDF]

, 2010
Aim: Patients undergoing bypass graft placement in the lower limb are often entered into a graft surveillance programme using duplex scanning. The aim of this programme is to identify stenoses in vein grafts before they become symptomatic and treat these
Cassar, Kevin, Cassar, Noel, Dunjic, Branko   +2 more
core  

A comparison of third-generation semi-invasive arterial waveform analysis with thermodilution in patients undergoing coronary surgery [PDF]

, 2012
Uncalibrated semi-invasive continous monitoring of cardiac index (CI) has recently gained increasing interest. The aim of the present study was to compare the accuracy of CI determination based on arterial waveform analysis with transpulmonary ...
Bein, Berthold, Broch, Ole, Grünewald, Matthias Lars, Malbrain, Manu, Meybohm, Patrick, Renner, Jochen, Schöttler, Jan, Steinfath, Markus   +7 more
core   +2 more sources