Results 241 to 250 of about 235,925 (318)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Comment on "Association between non-anemic iron deficiency and outcomes following off-pump coronary artery bypass surgery: a retrospective analysis". [PDF]

Korean J Anesthesiol
Hsu HA, Lin WT, Hung MH.
europepmc   +1 more source

Risk–Benefit of Phase 2 Monotherapy Trials in Adult Solid Cancers: A Systematic Review and Meta‐Analysis

International Journal of Cancer, EarlyView.
The therapeutic status of drug administration in phase 2 cancer trials is ambiguous, as these studies test efficacy without strong evidence of clinical benefit. Nonetheless, patients face meaningful risks. This review compared efficacy and safety of monotherapy drugs in phase 2 and phase 3 trials across six cancer types.
Charlotte Ouimet, Monica Rosu, Jonathan Kimmelman   +2 more
wiley   +1 more source

Concerns regarding the predictive use of thromboelastography in coronary bypass surgery. [PDF]

Ann Med
Sathian B, Iqbal J, Al Hamad H.
europepmc   +1 more source

Predictive Biomarkers in Metastatic Colorectal Cancer Patients Treated With Bevacizumab: A Turkish Oncology Group (TOG) Study

International Journal of Cancer, EarlyView.
Bevacizumab added to systemic chemotherapy remains a cornerstone of metastatic colorectal cancer treatment, but its effectiveness is variable. Tumors can bypass the VEGF blockade by activating other pro‐angiogenic pathways, hampering the identification of predictive biomarkers.
Büsra Akay Hacan, Fatma Gizem Sonugür, Müge Öçal, Cansu Babahan, Samira Abgarmi, Ülkü Yalçıntaş Arslan, Mehmet Ali Şendur, Ahmet Demirkazık, Güngör Utkan, Hakan Akbulut   +9 more
wiley   +1 more source

A Case of <i>de novo</i> aneurysm formation at the anastomosis site 3 years after superficial temporal artery-middle cerebral artery bypass surgery. [PDF]

Surg Neurol Int
Miyake T, Sakamoto Y, Nagatani T, Muraoka S, Saito R.   +4 more
europepmc   +1 more source

The FemTech revolution: Unlocking the potential of new technology for optimizing pregnancy outcomes in low‐ and middle‐income countries and remote areas

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Maternal and neonatal mortality and morbidity rates uncover major global health disparities. Despite ongoing efforts, the rates of maternal and neonatal complications remain substantially higher in low‐ and middle‐income countries (LMICs) compared to high‐income countries (HICs). These high rates are the result of several unmet needs in LMICs,
Nir Melamed, Hema Divakar, Mahesh Choolani, Fionnuala M. McAuliffe, Lin Foo, Hassan Shehata, Gabriel Jones, Vyta Senikas, Eline M. Van der Beek, Nandita Palshetkar, Gabriele Saccone, Vincenzo Berghella, Mauricio A. Cuello, Justin Konje, Bhaskar Bhatt, Augusto Cam, Moses Obimbo, Aris Papageorghiou, Moshe Hod, on behalf of the FIGO Committee on Women's Health and Technology   +19 more
wiley   +1 more source

Laparoscopic repair of internal hernia in pregnant women after Roux-en-Y gastric bypass surgery: a case report. [PDF]

J Surg Case Rep
Farran AE, Thomason RK, Koller Gorham JS.   +2 more
europepmc   +1 more source

Coronary Artery Bypass Surgery in Patients on Dialysis: In-Hospital Outcomes from UK Registry Analysis. [PDF]

Interdiscip Cardiovasc Thorac Surg
Mashat MA, Dong T, Kota R, Di Tommaso E, Narayan P, Tan C, Rajakaruna C, Mohamed Ahmed E, Angelini GD, Angelini GD, Fudulu DP.   +10 more
europepmc   +1 more source