Results 11 to 20 of about 3,099 (102)

Elevated Polyreactive Immunoglobulin G in Immune-Mediated Liver Injuries With the Need for Immunosuppressive Therapy. [PDF]

Liver Int
ABSTRACT Background & Aims The distinction of drug‐induced liver injury (DILI), drug‐induced autoimmune‐like hepatitis (DI‐ALH), and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics. Recently, polyreactive immunoglobulin G (pIgG) was identified as a novel biomarker in AIH.
Kirchner T, Dalekos GN, Zachou K, Robles-Díaz M, Andrade RJ, Sebode M, Lohse A, Janik MK, Milkiewicz P, Kolev M, Semmo N, Bruns T, Gevers TJ, Beretta-Piccoli BT, Wedemeyer H, Jaeckel E, Taubert R, Engel B, pIgG study group.   +18 more
europepmc   +2 more sources

Dual-Channel Fluorescence Assays with Supramolecular Host-Dye Reporter Pairs for Membrane Activity Mapping of Peptides. [PDF]

Angew Chem Int Ed Engl
Membrane‐active peptides (MAPs) such as cell‐penetrating peptides (CPPs) and antimicrobial peptides (AMPs) can translocate across lipid membranes and create membrane pores. The combination of a dye efflux and a supramolecular tandem membrane assay in a dual‐channel format enables an advanced mechanistic characterization and an exploration of the ...
Alnajjar MA, Schöpper SN, Pramod M, Reingolz T, Müller L, Neumann J, Nilam M, Nau WM, Hennig A.   +8 more
europepmc   +2 more sources

Molecular Investigation in Early-Onset Interstitial Lung Disease: Results From 699 Unrelated Patients. [PDF]

Respirology
ABSTRACT Background and Objective Interstitial lung diseases (ILDs) are rare and severe respiratory conditions that may ultimately result in pulmonary fibrosis (PF). The objective of this study was to present the results of molecular diagnosis of early‐onset ILD (from neonates to young adults < 50 years) in a reference genetic diagnostic laboratory ...
Louvrier C, Nathan N, Cottin V, Desroziers T, Nau V, Soreze Y, Dastot-Le Moal F, Reix P, Bouvry D, Thumerelle C, Reynaud-Gaubert M, Hadchouel A, Prévot G, Manali E, Kannengiesser C, Ba I, Amselem S, Houdouin V, Borie R, Legendre M, RespiRare and OrphaLung.   +20 more
europepmc   +2 more sources

Environmental Factors and Co-Occurrence Patterns Influence Dorsal Brightness in Two Jumping Mice Species in the Western United States. [PDF]

Ecol Evol
We examined how dorsal coloration varies in the endangered New Mexico jumping mouse (Zapus luteus) and its close relative, the western jumping mouse (Z. princeps) in relation to environmental variables and co‐occurence patterns using standardized photographs of museum specimens.
Martínez-Fonseca JG, Westeen EP, Zahratka JL, Chambers CL.   +3 more
europepmc   +2 more sources

Mimikry eines Lichtsammelkomplexes zur Beschleunigung der Photooxidation in asymmetrischen Lipidmembran‐Nanoreaktoren

Angewandte Chemie, EarlyView.
Biomimetische Liposomen‐Nanoreaktoren, die natürliche Lichtsammelkomplexe nachahmen, ermöglichen eine effiziente Photooxidation von NADH. Membrangebundenes Fluorescein überträgt Energie über FRET an membrangebundenes Eosin Y und oxidiert so NADH.
Julian Bösking, Roland E. P. Nau, Nico Alleva, Richard Jacobi, Tobias Meyer‐Zedler, Hannah Voßhenrich, Francesca Mazotta, Ingo Lieberwirth, David Ng, Michael Schmitt, Jürgen Popp, Leticia González, Tanja Weil, Andrea Pannwitz   +13 more
wiley   +1 more source

Mimicking a Light‐Harvesting Complex to Accelerate Photooxidation in Asymmetric Lipid Membrane Nanoreactors

Angewandte Chemie International Edition, EarlyView.
Biomimetic liposome nanoreactors mimicking natural light‐harvesting complexes enable efficient photooxidation of NADH. Membrane‐anchored fluorescein transfers energy via FRET to membrane anchored eosin Y, oxidizing NADH. While symmetric membranes show little improvement, asymmetric chromophore distribution enhances photooxidation rates by up to 27 ...
Julian Bösking, Roland E. P. Nau, Nico Alleva, Richard Jacobi, Tobias Meyer‐Zedler, Hannah Voßhenrich, Francesca Mazotta, Ingo Lieberwirth, David Ng, Michael Schmitt, Jürgen Popp, Leticia González, Tanja Weil, Andrea Pannwitz   +13 more
wiley   +1 more source

The Trajectory of an Agreement: Tracing Objectivated Knowledge Across a Series of Mundane Encounters

Symbolic Interaction, EarlyView.
This article adds to the sociological study of time and temporality in everyday life by building on recent longitudinal developments within conversation analysis. It investigates members' methods to bring about change within their shared (life) world. It examines how, as part of an extended project of action, one agreement made early on is continually ...
Sarah Hitzler, Jonas Kramer
wiley   +1 more source

Flecainide binding dynamics in voltage‐gated sodium channels: A comparative isoform analysis of the state‐dependent block

British Journal of Pharmacology, EarlyView.
Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata, Etsuko Kumada, Nao Katayama, Hiroki Nakagawa, Akihiko Sunami   +4 more
wiley   +1 more source

Evaluating FABP5 as a Therapeutic Target for Pain Management

European Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren, Myles Osborn, Martin Kaczocha, Andrew Yates, Saoirse O'Sullivan   +4 more
wiley   +1 more source

ĐÁNH GIÁ KHẢ NĂNG THAY THẾ ĐẠM BỘT CÁ BẰNG ĐẠM RONG BÚN (ENTEROMORPHA INTESTINALIS) TRONG ƯƠNG CÁ NÂU GIỐNG (SCATOPHAGUS ARGUS)

Tạp chí Khoa học Đại học Cần Thơ, 2013
Nghiên cứu đánh giá khả năng thay thế đạm bột cá bằng đạm bột rong bún (Enteromorpha intestinalis) làm thức ăn cho cá nâu (Scatophagus argus) giống. Nghiệm thức thức ăn đối chứng với nguồn cung cấp là đạm bột cá, 5 nghiệm thức còn lại có mức đạm bột cá ...
Nguyen Thi Ty Ni, Trần Ngọc Hải, Nguyễn Thị Ngọc Anh, Trần Thị Thanh Hiền   +3 more
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