Results 201 to 210 of about 713,196 (235)

Toward standardized iPSC testing: Insights from a multi-year international Quality Assessment Round. [PDF]

Stem Cell Reports
Hägg A, Wood R, Mochizuki AL, Abberton K, Abranches E, Alvarez-Palomo B, Baptista R, Quintanilha Barbosa RA, Barry J, Carvalho AB, Bennaceur Griscelli A, Campos de Carvalho AC, Chaker D, Chang H, Choi HY, Codinach M, Arán Corbella B, Cowan S, Dickerson SJ, Elwood N, Fan X, Feyeux M, Forrester M, Gaffney A, Guilbert SM, Ha HY, Hirst AJ, Hunter AL, Jamieson LG, Judson RN, Kanemura Y, Kasai-Brunswick TH, Kim JH, Kim H, Kintali M, Krishnan S, Kuebler B, Lau CY, Li W, Mack A, MacLeod MR, Madrid M, Mamiya H, Manache-Alberici L, Mărginean D, Mentre O, Morgan SL, Mountford J, Munir H, Ng SHS, Ogawa H, Oh S, Ohara H, Oono K, Park N, Pereira LV, Pereira da Silva Bezerra I, Podovei AR, Querol S, Raje J, Raya A, Sakamoto S, Sarafian R, Schmit K, Selvitella S, Singh G, Smart MJK, Song J, Stacey G, Sullivan S, Sumida M, Terrenoire C, Tian P, Uhlin E, Vaquero JMA, Veiga A, Vicky Wang JW, Warre-Cornish K, Wood J, Yamamoto A, Zhang G, Hikichi T, Turner M, Falk A.   +83 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Absorption, distribution, metabolism, and excretion of [¹⁴C]SH-1028, a third-generation <i>EGFR</i>-TKI, in rats and humans. [PDF]

Front Pharmacol
Zhou S, Wu Y, Liu W, Zhou C, Xie L, Zhuang Q, Wang L, Chen J, Zhu B, Zhang C, Zhang X, Shao F.   +11 more
europepmc   +1 more source

Modern Management of Asymptomatic Carotid Stenosis: A Meta‐Analysis of CREST‐2, SPACE‐2, and ECST‐2

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Recent randomized trials (CREST‐2, SPACE‐2, and ECST‐2) have compared carotid revascularization (carotid endarterectomy [CEA] or carotid artery stenting [CAS]) plus contemporary medical therapy (CMT) versus CMT alone in asymptomatic carotid stenosis.
Aasim Ali, Waqar Ahmed Cheema, Fiza Nisar, Muhammad Shamoon, Sameen Sarfaraz, Ahmad Butt, Muhammad Abdullah Ali, Armaghana Abdullah, Muhammad Asad Shabbir, Muhammad Talha, Hammad Azam, Aimen Anwaar Pannun, Usama Saleem, Anousha Tanveer, Mukesh Sharma   +14 more
wiley   +1 more source

Crucial Gram-positive type IV secretion system protein TraF is a structural homolog of type VII secretion system protein EssB/YukC. [PDF]

Microlife
Kuhlmann K, Stallinger A, Michaelis C, Berger TMI, Kohler V, Gesslbauer B, Pavkov-Keller T, Grohmann E, Keller W.   +8 more
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Genomic analysis of community-associated multidrug-resistant <i>Klebsiella quasipneumoniae</i> subsp. <i>similipneumoniae</i> and the identification of the ST2059-KL1 clone in the U.S. [PDF]

Microbiol Spectr
Jiang J, Terlecky AJ, Shashkina E, Starolis MW, Chen L, Kreiswirth BN.   +5 more
europepmc   +1 more source

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source

Generation of two isogenic sickle cell disease induced pluripotent stem cell lines from ovarian fibroblasts. [PDF]

Stem Cell Res
Harancher MR, Myklebust LK, Sukhwani M, Kanodia C, Sheng Y, Castro CA, Colvin Zielen AM, Orwig KE.   +7 more
europepmc   +1 more source