Results 51 to 60 of about 73,132 (261)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Trayectorias de los hogares argentinos según estrato social entre 1997 y 2006 [PDF]

open access: yes, 2010
Background of INCASI Project H2020-MSCA-RISE-2015 GA 691004. WP1: CompilationEn este trabajo analizamos la trayectoria de los hogares argentinos a partir de haber conformado un modelo de estratificación social des de una visión multidimensional.
Fachelli, Sandra
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Demanda d’activitats fisicoesportives de temps lliure. Estudi comparatiu entre l’alumnat d’Ensenyament Secundari Postobligatori de segon cicle de la Universitat d’Almeria [PDF]

open access: yes, 2004
Conèixer les demandes d’activitat física de temps lliure de l’alumnat almerienc d’Ensenyament Secundari Postobligatori (ESPO) i de segon cicle de la Universitat d’Almeria i les condicions en què li agradaria realitzar-la: modalitats, freqüència de ...
García Montes, M.ª Elena   +1 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Women prison of Málaga in Franco 's peace [PDF]

open access: yes, 2011
Este artículo pretende mostrar la situación de la cárcel de mujeres de Málaga desde que la ciudad fue ocupada el 8 de febrero de 1937 hasta 1945. Para su elaboración se han utilizado las fu entes documentales existentes en la Prisión Provincial, el ...
Barranquero, Encarnación   +1 more
core   +4 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

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