Results 11 to 20 of about 11,040 (158)

Residual disease after neoadjuvant chemoradiotherapy for oesophageal cancer: locations undetected by endoscopic biopsies in the preSANO trial

BJS (British Journal of Surgery), Volume 107, Issue 13, Page 1791-1800, December 2020., 2020
Remnant cancer missed by endoscopic biopsies was located in the mucosa in two‐thirds of patients with residual disease after neoadjuvant chemoradiotherapy (nCRT). One‐third of patients had residual disease in the submucosa underneath a tumour‐free mucosa. The yield of biopsies in active surveillance after nCRT could be improved by sampling larger areas
B. J. van der Wilk, B. M. Eyck, M. Doukas, M. C. W. Spaander, E. J. Schoon, K. K. Krishnadath, L. E. Oostenbrug, S. M. Lagarde, B. P. L. Wijnhoven, L. H. J. Looijenga, K. Biermann, J. J. B. van Lanschot   +11 more
wiley   +1 more source

Geographical differences in cancer treatment and survival for patients with oesophageal and gastro‐oesophageal junctional cancers

BJS (British Journal of Surgery), Volume 107, Issue 11, Page 1500-1509, October 2020., 2020
This national cohort study of 5959 patients with oesophageal and gastro‐oesophageal junction (GOJ) cancer showed improved survival for patients in counties with a higher rate of treatment with curative intent and higher resection rate. Explanation needed Background Only around one‐quarter of patients with cancer of the oesophagus and the gastro ...
C. Jestin Hannan, G. Linder, C.‐H. Kung, J. Johansson, M. Lindblad, J. Hedberg   +5 more
wiley   +1 more source

Physiological performance and inflammatory markers as indicators of complications after oesophageal cancer surgery

BJS Open, Volume 4, Issue 5, Page 840-846, October 2020., 2020
C‐reactive protein concentration and peak oxygen uptake are collective independent risk factors that can account for over half of major morbidity following oesophagectomy for oesophageal cancer. A composite risk score, the Combined Inflammatory and Physiology Score (CIPS) (range 0–2), predicted major morbidity (17·9 per cent in patients with a CIPS of ...
A. G. M. T. Powell, C. Eley, T. Abdelrahman, A. H. Coxon, C. Chin, I. Appadurai, R. Davies, D. M. Bailey, W. G. Lewis   +8 more
wiley   +1 more source

Minimally invasive techniques for transthoracic oesophagectomy for oesophageal cancer: systematic review and network meta‐analysis

BJS Open, Volume 4, Issue 5, Page 787-803, October 2020., 2020
Minimally invasive and robotic techniques for oesophagectomy are associated with reduced perioperative morbidity and length of hospital stay, with no compromise of oncological outcomes but no improvement in perioperative mortality. There are suggestions of improved long‐term survival with minimally invasive oesophagectomy and robotic minimally invasive
K. Siaw‐Acheampong, S. K. Kamarajah, R. Gujjuri, J. R. Bundred, P. Singh, E. A. Griffiths   +5 more
wiley   +1 more source

Thromboembolic and bleeding complications in patients with oesophageal cancer

BJS (British Journal of Surgery), Volume 107, Issue 10, Page 1324-1333, September 2020., 2020
A total of 511 patients who underwent curative chemoradiotherapy and subsequent tumour resection for oesophageal cancer were reviewed retrospectively for bleeding events and arterial or venous thromboembolism (VTE). During the 2‐year follow‐up, 50 patients (9·8 per cent) developed VTE, 20 (3·9 per cent) arterial thromboembolism, 21 (4·1 per cent) major
F. I. Mulder, A. Hovenkamp, H. W. M. van Laarhoven, H. R. Büller, P. W. Kamphuisen, M. C. C. M. Hulshof, M. I. van Berge Henegouwen, S. Middeldorp, N. van Es   +8 more
wiley   +1 more source

Propensity score regression analysis of oesophageal adenocarcinoma treatment with surgery alone or neoadjuvant chemotherapy

BJS Open, Volume 4, Issue 4, Page 593-600, August 2020., 2020
Following propensity adjustment for stage, age and sex, neoadjuvant therapy was not associated with survival. Tumour regression is a powerful prognostic indicator, and future research should focus on identifying patients who will derive the most benefit from neoadjuvant chemotherapy.
A. G. M. T. Powell, A. Karran, P. Blake, A. Christian, S. A. Roberts, W. G. Lewis   +5 more
wiley   +1 more source

Liquid biopsy for cancer diagnosis using vibrational spectroscopy: systematic review

BJS Open, Volume 4, Issue 4, Page 554-562, August 2020., 2020
This article provides a systematic review of analysis by vibrational spectroscopy (VS) of human blood for cancer diagnosis – a spectral ‘liquid biopsy’. VS showed high potential for cancer diagnosis, but standardized reporting methods and more robust studies are needed before its value in clinical practice can be determined.
D. J. Anderson, R. G. Anderson, S. J. Moug, M. J. Baker   +3 more
wiley   +1 more source

Prognostic and predictive values of tumour budding in stage IV colorectal cancer

BJS Open, Volume 4, Issue 4, Page 693-703, August 2020., 2020
In stage IV colorectal cancer, tumour budding graded by International Tumor Budding Consensus Conference criteria is an important morphological marker that can predict prognosis and, possibly, tumour chemoresistance. The clinical relevance was maintained consistently in both resection subgroups (R0/R1 and R2/unresected).
K. Nagata, E. Shinto, M. Yamadera, T. Shiraishi, Y. Kajiwara, K. Okamoto, S. Mochizuki, K. Hase, Y. Kishi, H. Ueno   +9 more
wiley   +1 more source

Impact of co‐morbidities on health‐related quality of life 10 years after surgical treatment of oesophageal cancer

BJS Open, Volume 4, Issue 4, Page 601-604, August 2020., 2020
This study investigated the impact of co‐morbidities on health‐related quality of life during long‐term follow‐up after oesophagectomy. The results showed that the substantial impact of co‐morbidities on reported general health might be associated with symptoms and health‐related quality of life 10 years after oesophageal cancer treatment.
F. Klevebro, A. Johar, P. Lagergren
wiley   +1 more source

Machine learning to predict early recurrence after oesophageal cancer surgery

BJS (British Journal of Surgery), Volume 107, Issue 8, Page 1042-1052, July 2020., 2020
Early recurrence after surgery for adenocarcinoma of the oesophagus is common. A risk prediction model was derived using modern machine learning methods that accurately predicts risk of early recurrence using postoperative pathology. Machine learning may help Background Early cancer recurrence after oesophagectomy is a common problem, with an incidence
S. A. Rahman, R. C. Walker, M. A. Lloyd, B. L. Grace, G. I. van Boxel, B. F. Kingma, J. P. Ruurda, R. van Hillegersberg, S. Harris, S. Parsons, S. Mercer, E. A. Griffiths, J. R. O'Neill, R. Turkington, R. C. Fitzgerald, T. J. Underwood, the OCCAMS Consortium, Ayesha Noorani, Rachael Fels Elliott, Paul A.W. Edwards, Nicola Grehan, Barbara Nutzinger, Jason Crawte, Hamza Chettouh, Gianmarco Contino, Xiaodun Li, Eleanor Gregson, Sebastian Zeki, Rachel de la Rue, Shalini Malhotra, Simon Tavaré, Andy G. Lynch, Mike L. Smith, Jim Davies, Charles Crichton, Nick Carroll, Peter Safranek, Andrew Hindmarsh, Vijayendran Sujendran, Stephen J. Hayes, Yeng Ang, Shaun R. Preston, Sarah Oakes, Izhar Bagwan, Vicki Save, Richard J.E. Skipworth, Ted R. Hupp, J. Robert O'Neill, Olga Tucker, Andrew Beggs, Philippe Taniere, Sonia Puig, Timothy J. Underwood, Fergus Noble, James P. Byrne, Jamie J. Kelly, Jack Owsley, Hugh Barr, Neil Shepherd, Oliver Old, Jesper Lagergren, James Gossage, Andrew Davies Fuju Chang, Janine Zylstra, Vicky Goh, Francesca D. Ciccarelli, Grant Sanders, Richard Berrisford, Catherine Harden, David Bunting, Mike Lewis, Ed Cheong, Bhaskar Kumar, Simon L. Parsons, Irshad Soomro, Philip Kaye, John Saunders, Laurence Lovat, Rehan Haidry, Victor Eneh, Laszlo Igali, Michael Scott, Shamila Sothi, Sari Suortamo, Suzy Lishman, George B. Hanna, Christopher J. Peters, Anna Grabowska   +87 more
wiley   +1 more source