Results 111 to 120 of about 61,158,239 (269)

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Situación del cáncer de mama en la región de Azuero [PDF]

Breast cancer in the Azuero region has a high percentage in adult women, who after collecting data and medical consultations with at least 96 breast cancer patients, and among the factors, we can mention the highest incidence are: genetic factor, lack of
Mendoza, Julia, Bustavino, Paola, Castillo, Alisson, Sandoval, Nataly, Solis, Osvaldo, Rodríguez, Johnny, Baltazar, Jahir   +6 more
core   +1 more source

Efectos psicológicos relacionados con la quimioterapia en pacientes oncológicos con cáncer de mama

, 2020
El presente artículo tiene como objetivo reconocer los efectos psicológicos secundarios relacionados con la quimioterapia en pacientes con cáncer de mama , mediante la revisión de diversas investigaciones que plantean la relación en diferentes categorías
Méndez Bernal, Diego Andres, Villarraga Velandia, Julieth Vanessa   +1 more
core   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Cáncer de mama

Cirugía del Uruguay, 1984
Del panel discusión surge claramente el valor de la anamnesis y examen en el diagnóstico del cáncer de mama evaluando su eficacia diagnóstica en un 94%. El diagnóstico se reafirma por los diversos exámenes complementarios solicitados según un algorritmo ...
Alberto Aguiar, Miguel Musé, Agustín D'Auria, Félix Leborgne, Miguel Musé, Julio C Priario, Roberto Estrugo, Arturo Wilks, Jorge Maggiolo, Graciela Sabini, Jorge Vercelli   +10 more
doaj  

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Caracterización de los resultados de pruebas de inmunohistoquímica en mujeres pre menopáusicas y post menopáusicas con diagnóstico de cáncer de mama atendidas en el Hospital de Especialidades Eugenio Espejo entre el periodo 2013-2015

, 2016
El cáncer de mama es una patología de afectación mundial, siendo las pruebas genéticas de difícil acceso para nuestra población, se utiliza el perfil inmunohistoquímica, para correlacionar con los factores pronósticos y tratamiento.
Pazmiño Miranda, María Fernanda, López Sosa, Carlos Alberto   +1 more
core  

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source