Results 321 to 330 of about 183,594 (330)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano +6 more
wiley +1 more source
Lymph node assessment in patients with early-stage breast cancer: the current role of imaging methods. [PDF]
Radiol BrasTeixeira SRC, Bitencourt AGV.
europepmc +1 more source
Cancer Science, EarlyView.The combination of the Aurora‐A kinase inhibitor MLN8237 and the BH3 mimetic ABT263 enhanced anti‐tumor immunity by boosting CD8+ T cells and natural killer cells, while reducing immunosuppressive cells in the tumor microenvironment. It induced apoptosis via extrinsic and intrinsic pathways with minimal toxicity, offering a promising therapeutic ...
Mingxue Liu +4 more
wiley +1 more source
Identification of a Distal Enhancer That Regulates TGF‐β–Induced SNAI1 Expression
Cancer Science, EarlyView.In TGF‐β–stimulated cells, the activated Smad complex composed of Smad3 and Smad4 associates with the distal super enhancer region 2 (DSE2) and enhances its interaction with the SNAI1 proximal promoter, thus inducing SNAI1 expression. RREB1 regulates the basal activity of the enhancer but not its inducibility by TGF‐β.
Hao Fu +6 more
wiley +1 more source
Analysis of the indications for and results of breast cancer screening by magnetic resonance imaging at a cancer center in Brazil. [PDF]
Radiol BrasZoghbi KK +5 more
europepmc +1 more source
OCT‐2 Is Associated With Pro‐Metastatic Epigenomic Properties of Triple‐Negative Breast Cancer Cells
Cancer Science, EarlyView.The transcription factor OCT‐2 (encoded by POU2F2) is involved in the formation of super‐enhancers (SEs) in triple‐negative breast cancer (TNBC) cells. Overexpression of POU2F2 enhances the metastasis of TNBC cells in mice, and their expression is highly correlated to the poor prognosis of TNBC patients. ABSTRACT Triple‐negative breast cancer (TNBC) is
Kazuki Ogikubo +7 more
wiley +1 more source
Cancer Science, EarlyView.Our study reveals that hypoxia inhibitors ameliorate iodine uptake dysfunction in thyroid cancer by acting on the hsa_circ_0023990/miR‐448/DNMT1/NIS signaling pathway. ABSTRACT This research seeks to investigate how hypoxia inhibitors enhance iodine uptake in thyroid cancer cells. Clinical samples were gathered and assessed for hsa_circ_0023990, DNMT1,
Ruiqin Gou +5 more
wiley +1 more source
Cancer Science, EarlyView.A humanized cancer‐specific anti‐podoplanin monoclonal antibody humPMab‐117 exerts antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against human tumor cells. In the xenograft tumor models, humPMab‐117 demonstrated strong antitumor efficacy.
Tomohiro Tanaka +5 more
wiley +1 more source