Results 171 to 180 of about 8,237,739 (337)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Carotid reconstruction in patients operated for malignant head and neck neoplasia

São Paulo Medical Journal
CONTEXT: Patients with malignant head and neck neoplasia may present simultaneous involvement of large vessels due to the growth of the tumoral mass. The therapeutic options are chemotherapy, radiotherapy, surgery or combined treatments.
Kenji Nishinari, Nelson Wolosker, Guilherme Yazbek, Luiz Caetano Malavolta, Antônio Eduardo Zerati, Luiz Paulo Kowalski   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Las ciencias de la implementación y la prevención y control de cáncer

Gaceta Mexicana de Oncolog�a
¿Cómo incorporamos o aumentamos el uso de «cosas» que sabemos funcionan para la prevención y el control de cáncer?
openaire   +2 more sources

El rol de la cirugía en el manejo integral del cáncer de colon: ¿dónde estamos y hacia dónde vamos?

Revista de Cirugía Colorrectal
El cáncer de colon es actualmente la primera causa de muerte por cáncer; por ello, la atención médica debe estandarizarse desde el primer nivel de atención hasta los centros médicos de tercer nivel. El tratamiento quirúrgico del cáncer de colon es fundamental, ya sea en enfermedad localizada o metastásica. Como la mayoría de los pacientes (hasta el 70%)
Mónica P. Hernández-Molina, Sergio U. Pérez-Escobedo, Diego R. Mendoza-Díaz, Christhopher Flores-Rivera, Cristian J. Flores-González, Juan A. Villanueva-Herrero, Itzel Vela-Sarmiento, Billy Jiménez-Bobadilla, Noelia B. Fernández-Baez, Sharon J. Sánchez-Lara, Angie Vargas-Rodríguez, Carlos A. López-Bernal   +11 more
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Autocuidado e apoio social em mulheres do Núcleo Mama Porto Alegre [PDF]

, 2014
Breast cancer is one the most prevalent types of cancer among women. Many causes are known, ranging from the biological to the psychosocial. In Rio Grande do Sul, especially in Porto Alegre, occurrence rates and fatalities due to breast cancer are some ...
Hermel, Júlia Schneider
core  

Análisis de las características clínicas y resultados de cirugía en pacientes con cáncer colorrectal en un hospital de tercer nivel en México tras regular la atención hospitalaria por la emergencia sanitaria de COVID-19

Revista de Cirugía Colorrectal
Objetivo: El cáncer colorrectal (CCR) figura como la tercera neoplasia más frecuente a nivel mundial. Sin embargo, la atención médica de esta enfermedad se vio interrumpida durante la pandemia de COVID-19, lo que ocasionó retrasos en el diagnóstico y tratamiento del CCR.
Abelardo Juanz-González, Samanta K. Dosal-Limón, Alejandro Vela-Torres, Billy Jiménez-Bobadilla, Juan A. Villanueva-Herrero, Gerardo J. Maya-Vacío, Ana J. Iberri-Jaime, Jorge L. De León-Rendón   +7 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source