Results 181 to 190 of about 8,237,739 (337)

RESPONSE BY FLOW CYTOMETRY IN PATIENTS WITH BURKITT'S LYMPHOMA AND SECONDARY INVOLVEMENT IN THE CSF

Hematology, Transfusion and Cell Therapy
Introduction: Central nervous system (CNS) involvement is a poor prognostic factor of non-Hodgkin's lymphoma (NHL) in children. Therefore, early diagnosis and treatment of CNS disease is important to improve long-term disease-free survival rates in ...
GCF Souza, BP Martins, YA Moura, AP Dutra, LGPME Souza, BF Baglioli, R Balceiro, JL Neves, AF Oliveira, MJA Paula   +9 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

CENTRAL NERVOUS SYSTEM INVOLVEMENT IN HODGKIN'S LYMPHOMA ASSOCIATED WITH EPSTEIN-BARR VIRUS IN A PATIENT WITHOUT HIV INFECTION IN PREVIOUS HEALTHY CHILDREN

Hematology, Transfusion and Cell Therapy
Introduction: Hodgkin lymphoma (HL), unlike non-Hodgkin lymphoma, rarely involves the central nervous system (CNS). The incidence has been reported as 0.2% to 0.5% of all HL cases, but a recent review of 14 868 patients identified only 2 cases of HL ...
GCF Souza, BP Martins, YA Moura, AP Dutra, LGPME Souza, BF Baglioli, R Balceiro, JL Neves, A Frisanco, MJA Paula   +9 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Análise de tendência temporal das internações e dos óbitos por câncer de pele nas cinco regiões do Brasil, 1995-2009. [PDF]

, 2011
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Casagrande, Ana luiza Baldissera
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Efeito térmico da cirurgia de alta frequência no tecido do colo uterino [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências MédicasIntrodução: O câncer de colo uterino constitui um problema de saúde pública relevante, devido à sua alta incidência
Sommacal, Luiz Fernando
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

SARCOMA HISTIOCÍTICO: UMA NECESSIDADE MÉDICA NÃO ATINGIDA COM DESFECHOS DESFAVORÁVEIS

Hematology, Transfusion and Cell Therapy
Introdução: O Sarcoma Histiocítico Verdadeiro (SHV) é uma neoplasia rara derivada de histiócitos, caracterizada por apresentação agressiva e respostas insatisfatórias a quimioterápicos clássicos.
JA Balthazar, JC Amarante, AL Oliveira, FD Costa, T Fischer, JS Filho, T Silveira   +6 more
doaj   +1 more source

Carcinoma mamário bilateral: revisão bibliográfica e apresentação de cinco casos. [PDF]

, 1996
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Tocoginecologia, Curso de Medicina, Florianópolis ...
Viana, Deise Lane
core