Results 211 to 220 of about 8,237,739 (337)
Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski +14 morewiley +1 more sourceInvestigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov +10 morewiley +1 more sourceIntegrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar +13 morewiley +1 more sourceYAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna +9 morewiley +1 more sourceEmerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger +3 morewiley +1 more sourceGut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte +7 morewiley +1 more sourceGlobal surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries
The Lancet, 2018 C. Allemani, T. Matsuda, V. D. Carlo, R. Harewood, M. Matz, M. Nikšić, A. Bonaventure, M. Valkov, Christopher J. Johnson, J. Estève, O. Ogunbiyi, G. A. Silva, Wanqing Chen, S. Eser, G. Engholm, C. Stiller, A. Monnereau, R. Woods, O. Visser, G. Lim, J. Aitken, H. Weir, M. Coleman, S. Bouzbid, M. Hamdi-Chérif, Z. Zaidi, K. Meguenni, D. Regagba, S. Bayo, T. C. Bougadari, S. Manraj, K. Bendahhou, A. Fabowale, D. Bradshaw, N. Somdyala, I. Kumcher, F. Moreno, G. Calabrano, S. Espinola, B. C. Quintero, R. Fita, M. Diumenjo, W. Laspada, S. G. Ibañez, C. A. Lima, P. C. Souza, K. D. Pino, C. Laporte, M. Curado, J. C. D. Oliveira, C. Veneziano, D. Veneziano, M. Latorre, L. F. Tanaka, M. Rebelo, M. O. Santos, J. Galaz, M. Aravena, J. S. Monsalve, D. Herrmann, Sergio L Vargas, V. Herrera, C. Uribe, L. Bravo, L. García, N. Arias-Ortiz, D. Morantes, D. Jurado, M. Chamorro, S. Delgado, M. Ramirez, Y. G. Álvarez, P. Torres, F. Martínez-Reyes, L. Jaramillo, R. Quinto, J. Castillo, M. Mendoza, P. Cueva, J. G. Yépez, B. Bhakkan, J. Deloumeaux, C. Joachim, J. Macni, R. Carrillo, J. S. Klincovstein, R. Gómez, E. Poquioma, G. Tortolero-Luna, D. Zavala, R. Alonso, E. Barrios, A. Eckstrand, C. Nikiforuk, G. Noonan, D. Turner, E. Kumar, B. Zhang, F. McCrate, S. Ryan, M. MacIntyre, N. Saint-Jacques, D. Nishri, C. McClure, K. Vriends, S. Kozie, H. Stuart-Panko, T. Freeman, J. George, J. Brockhouse, D. O’Brien, A. Holt, L. Almon, S. Kwong, C. Morris, R. Rycroft, L. Mueller, C. Phillips, H. Brown, B. Cromartie, A. Schwartz, F. Vigneau, G. Levin, B. Wohler, R. Bayakly, K. Ward, S. Gomez, M. McKinley, R. Cress, M. Green, K. Miyagi, L. Ruppert, C. Lynch, B. Huang, T. Tucker, D. Deapen, L. Liu, M. Hsieh, X. C. Wu, M. Schwenn, S. Gershman, R. Knowlton, G. Alverson, G. Copeland, S. Bushhouse, D. Rogers, J. Jackson-Thompson, D. Lemons, H. Zimmerman, M. Hood, J. Roberts-Johnson, J. Rees, B. Riddle, K. Pawlish, A. Stroup, C. Key, C. Wiggins, A. Kahn, M. Schymura, S. Radhakrishnan, C. Rao, L. Giljahn, R. Slocumb, R. Espinoza, F. Khan, K. G. Aird, T. Beran, J. Rubertone, S. Slack, L. García, D. L. Rousseau, T. Janes, S. Schwartz, S. Bolick, D. Hurley, M. Whiteside, P. Miller-Gianturco, M. Williams, K. Herget, C. Sweeney, A. Johnson, M. K. Cheteri, P. M. Santiago, S. Blankenship, S. Farley, R. Borchers, R. Malicki, J. Espinoza, J. Grandpré, R. Wilson, B. Edwards, A. Mariotto, Y. Lei, N. Wang, J. S. Chen, Y. Zhou, Y. He, G. Song, X. Gu, D. Mei, H. Mu, H. Ge, T. H. Wu, Y. Y. Li, D. Zhao, F. Jin, J. Zhang, F. Zhu, Q. Junhua, Y. L. Yang, C. Jiang, W. Biao, J. Wang, Q. L. Li, H. Yi, X. Zhou, J. Dong, W. Li, F. Fu, S. Z. Liu, J. G. Chen, J. Zhu, Y. H. Li, Y. Q. Lu, M. Fan, S. Huang, G. Guo, H. Zhaolai, K. Wei, H. Zeng, A. Demetriou, W. K. Mang, K. Ngan, A. Kataki, M. Krishnatreya, P. Jayalekshmi, P. Sebastián, A. Nandakumar, R. Malekzadeh, G. Roshandel, L. Keinan-Boker, B. Silverman, H. Ito, H. Nakagawa, M. Sato, F. Tobori, I. Nakata, N. Teramoto, M. Hattori, Y. Kaizaki, F. Moki, H. Sugiyama, M. Utada, M. Nishimura, K. Yoshida, K. Kurosawa, Y. Nemoto, H. Narimatsu, M. Sakaguchi, S. Kanemura, M. Naito, R. Narisawa, I. Miyashiro, K. Nakata, S. Sato, M. Yoshii, I. Oki, N. Fukushima, A. Shibata, K. Iwasa, C. Ono, O. Nimri, K. Jung, Y. Won, E. Alawadhi, A. Elbasmi, A. A. Manan, F. Adam, E. Sanjaajmats, U. Tudev, C. Ochir, A. Khater, M. E. Mistiri, Y. Teo, C. Chiang, W. C. Lee, R. Buasom, S. Sangrajrang, S. Kamsa-ard, S. Wiangnon, K. Daoprasert, D. Pongnikorn, A. Leklob, S. Sangkitipaiboon, S. Geater, H. Sriplung, O. Ceylan, I. Kög, O. Dirican, T. Köse, T. Gurbuz, F. Karaşahin, D. Turhan, U. Aktaş, Y. Halat, C. Yakut, M. Altınışık, Y. Cavusoglu, A. Türkköylü, N. Üçüncü, M. Hackl, A. Zborovskaya, O. Aleinikova, K. Henau, L. V. Eycken, Z. Valerianova, M. Yordanova, M. Šekerija, L. Dusek, M. Zvolský, H. Storm, K. Innos, M. Mägi, N. Malila, K. Seppä, J. Jegu, M. Velten, E. Cornet, X. Troussard, A. Bouvier, A. Guizard, V. Bouvier, G. Launoy, P. Arveux, M. Maynadie, M. Mounier, A. Woronoff, M. Daoulas, M. Robaszkiewicz, J. Clavel, S. Goujon, B. Lacour, I. Baldi, C. Pouchieu, B. Amadéo, G. Coureau, S. Orazio, P. Preux, F. Rharbaoui, É. Marrer, B. Trétarre, M. Colonna, P. Delafosse, K. Ligier, S. Plouvier, A. Cowppli-Bony, F. Molinié, S. Bara, O. Ganry, B. Lapôtre‐Ledoux, P. Grosclaude, N. Bossard, Z. Uhry, F. Bray, M. Piñeros, R. Stabenow, H. Wilsdorf-Köhler, A. Eberle, S. Luttmann, I. Löhden, A. Nennecke, J. Kieschke, E. Sirri, K. Emrich, S. Zeissig, B. Holleczek, N. Eisemann, A. Katalinic, R. Asquez, V. Kumar, E. Petridou, E. Ólafsdóttir, L. Tryggvadottir, K. Clough-Gorr, P. Walsh, H. Sundseth, G. Mazzoleni, F. Vittadello, E. Coviello, F. Cuccaro, R. Galasso, G. Sampietro, A. Giacomin, M. Magoni, A. Ardizzone, A. D'Argenzio, M. Castaing, G. Grosso, A. Lavecchia, A. Sardo, G. Gola, L. Gatti, P. Ricci, S. Ferretti, D. Serraino, A. Zucchetto, M. Celesia, R. Filiberti, F. Pannozzo, A. Melcarne, F. Quarta, A. Russo, G. Carrozzi, C. Cirilli, L. C. d’Oro, M. Rognoni, M. Fusco, M. Vitale, M. Usala, R. Cusimano, W. Mazzucco, M. Michiara, P. Sgargi, L. Boschetti, E. Borciani, P. Seghini, M. Maule, F. Merletti, R. Tumino, P. Mancuso, M. Vicentini, T. Cassetti, R. Sassatelli, F. Falcini, S. Giorgetti, A. Caiazzo, R. Cavallo, R. Cesaraccio, D. Pirino, M. L. Contrino, F. Tisano, A. Fanetti, S. Maspero, S. Carone, A. Mincuzzi, G. Candela, T. Scuderi, M. Gentilini, S. Piffer, S. Rosso, A. Barchielli, A. Caldarella, F. Bianconi, F. Stracci, P. Contiero, G. Tagliabue, M. Rugge, M. Zorzi, S. Beggiato, A. Brustolin, F. Berrino, G. Gatta, M. Sant, C. Buzzoni, L. Mangone, R. Capocaccia, R. Angelis, R. Zanetti, A. Maurina, S. Pildava, N. Lipunova, I. Vincerzevskiene, D. Agius, N. Calleja, S. Siesling, S. Larønningen, B. Møller, A. Dyzmann-Sroka, M. Trojanowski, S. Góźdź, R. Mężyk, T. Mierzwa, L. Molong, J. Rachtan, S. Szewczyk, J. Błaszczyk, K. Kępska, B. Kościańska, K. Tarocińska, M. Zwierko, K. Drosik, K. M. Maksimowicz, E. Purwin-Porowska, E. Reca, J. Wójcik-Tomaszewska, A. Tukiendorf, M. Grądalska-Lampart, A. Radziszewska, A. Gos, M. Talerczyk +499 moresemanticscholar +1 more source
