Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Câncer de colo uterino: conhecimento e comportamento de mulheres para prevenção [PDF]
, 2015 Alanda Maria Rodrigues Santos +4 more
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
O Instagram e a fotografia – A favor das mulheres com câncer
Revista Alterjor, 2018 Este artigo apresenta o início de uma pesquisa sobre as postagens das mulheres com câncer e como elas se relacionam com as fotografias e com os conteúdos que compartilham no Instagram. Objetiva-se apresentar a possibilidade de evolução do estado de saúde
Dalila Penteado
doaj
Carcinoma mamário bilateral: revisão bibliográfica e apresentação de cinco casos. [PDF]
, 1996 Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Tocoginecologia, Curso de Medicina, Florianópolis ...
Viana, Deise Lane
core
Resistência à terapia endócrina no câncer de mama – Relato de caso / Resistance to endocrine therapy in breast cancer - Case report [PDF]
, 2021 Luisa Weffort Vicente +5 more
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Percepções de pacientes com câncer quanto ao conhecimento e revelação deste diagnóstico [PDF]
, 2004 Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Souza, Luciana Hammes de
core
As (im)possibilidades de brincar para o escolar com câncer em tratamento ambulatorial [PDF]
, 2010 Liliane Faria da Silva +2 more
openalex +1 more source