Results 241 to 250 of about 3,585,369 (296)

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Targeting Tumorigenic Coactivators in the PI3K/AKT Signaling Pathway: A Novel Approach for Cancer Treatment. [PDF]

Cancer Med
Haque MA, Poullikkas T, Kaisar FMA, Khan A, Haque S, Mollik M, Mowa MJ, Khatun MH, Mamun A, Bithy MBA.   +9 more
europepmc   +1 more source

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, EarlyView.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

Single rate-limiting event of carcinogenesis. [PDF]

Nat Commun
Yasui Y, Liu Q.
europepmc   +1 more source

Análise molecular da mutação BRAF V600E e da instabilidade de microssatélites em portadores de câncer de cólon e reto do Sul do Brasil

, 2016
Érika Pereira Zambalde
openalex   +1 more source

RASTREAMENTO DO CÂNCER DO COLO DO ÚTERO NO BRASIL: AVANÇOS, DESAFIOS E PERSPECTIVAS NA ATENÇÃO PRIMÁRIA

Daniel Magno Charone, ANA BEATRIZ ACIOLI FARIA, YASMIN CAVALLEIRO DE MACEDO MARANHÃO, MARIANA CALUFF CANTO, ANA LUIZA PESSOA SILVA   +4 more
openalex   +1 more source

Estratégias Educativas para Prevenção e Redução da Morbimortalidade do Câncer do Colo Uterino

, 2015
Gilberto de Souza, Priscilla Santos Alves   +1 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Real-world data and clinical experience from over 100,000 multi-cancer early detection tests. [PDF]

Nat Commun
Matrana M, Shukla V, Kingsbury D, Poliak M, Lipton J, McMillin M, Malinow LB, Venn O, Beausang JF, Stanley G, Hubbell E, Kurtzman KN, Venstrom JM, Shaknovich R, Westgate C.   +14 more
europepmc   +1 more source

CONTRIBUIÇÕES DO PROFISSIONAL BIOMÉDICO NA TRIAGEM, PREVENÇÃO E DIAGNÓSTICO DO CÂNCER CERVICAL NO AMAZONAS

Jamylly Vicktoria Araújo Dorzane, Bruna da Silva Souza Avelino   +1 more
openalex   +1 more source