Results 271 to 280 of about 3,585,369 (296)

The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies

Molecular Oncology, EarlyView.
RAS‐targeted therapies have become a clinical reality. Although promising results in patients have been achieved, there are still challenges ahead such as coping with drug resistance. Here we summarize selected RAS inhibitors targeting either individual KRAS mutant isoforms (KRASG12C, KRASG12D, KRASG12V) or exhibiting a wider inhibitory spectrum ...
Matthias Drosten, Mariano Barbacid
wiley   +1 more source

Direct medical cost analysis of breast cancer treatment at Jimma University Medical Center: a provider perspective. [PDF]

Cost Eff Resour Alloc
Edessa GJ, Kare KA, Edessa AJ, Daka DW.
europepmc   +1 more source

Mortalidade por câncer em militares da Marinha do Brasil

, 2000
Silva Marlene, Santana Vilma S, Loomis Dana   +2 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Drug Targets in Prostate Cancer: An Appetite for KLK2-Mediated Destruction. [PDF]

Clin Cancer Res
Blinka S, Yu EY.
europepmc   +1 more source

O impacto na imagem corporal e qualidade de vida das pacientes com câncer de mama

Andressa Kasse Figueiro Mastrangelli, Vânia Lopes Pinto, Simone Elias   +2 more
openalex   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Retrospective study: the value of GDF-15 and conventional markers in combination for clinical diagnosis of lung cancer. [PDF]

PeerJ
Ni J, Hao X, Wu Y, Mao C, Niu L, Liu H, Lin Q.   +6 more
europepmc   +1 more source

INIBIDORES DO CHECKPOINT IMUNOLÓGICO NO TRATAMENTO DE CÂNCER: REVISÃO DE LITERATURA

Overland Gabriel Santos Bastos, Wesley Wander Negrão Fonseca, Luydson Richardson Silva Vasconcelos, FERNANDO SANTA MARIA ABRAÇADO AMARAL, MATEUS MEDEIROS DE PAIVA CAVALCANTE   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source