Results 321 to 330 of about 8,254,551 (385)

Significado da recidiva local no tratamento conservador do câncer de mama

, 2022
Jorge V. Biazús, Carlos H. Menke, José A. Cavalheiro, Nilton L. Xavier, Rodrigo Cericatto, Ana C. Bittelbrun, Eliane G. Rabin   +6 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Avaliação da instabilidade genômica e prevenção de câncer

, 2022
Sharbel W. Maluf, Mariluce Riegel, Silvio L.W. Almeida Jr, Janaína P. Jaeger, Ana P.B. Souza, Valcinete F. Santana, Luiza E. Dorfman, Gisele B. Trombetta, Alexandre Bacelar, Bernardo Erdtmann   +9 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Consideration of inherited cancer risk on a continuum: An international and multidisciplinary perspective: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG). [PDF]

Genet Med
Pal T, Christopher J, Astiazaran-Symonds E, Foulkes WD, James P, Klugman S, Kurian A, Mak J, Monteiro A, Robson M, Tischkowitz M, Stewart DR, Hanson H, ACMG Professional Practice and Guidelines Committee. Electronic address: documents@acmg.net.   +13 more
europepmc   +1 more source

O RASTREIO DO CÂNCER DO COLO UTERINO EFICIENTE: NOVO DESAFIO BRASILEIRO

Ana Tercia Beltrame Carvalho, Enzo Brito Teixeira, Maria de Fátima Dias de Sousa Brito   +2 more
openalex   +1 more source

Detecção precoce do câncer de pele: experiência de campanha de prevenção no Piauí-Brasil

, 2012
Rafael Bandeira Lages, Patrícia Barros Barbosa, Isabella Parente Almeida, Lauro Rodolpho Soares Lopes, Lauro Lourival Lopes Filho   +4 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source