Results 101 to 110 of about 387,579 (200)

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Additive Manufacturing of High‐Performance Polymers for Extreme Environments

Advanced Science, EarlyView.
Additive manufacturing of high‐performance polymers for extreme environments is critically reviewed through an integrated chemistry‐processing‐structure‐property‐qualification framework. The review compares fused filament fabrication, selective laser sintering, and direct ink writing, linking rheology and thermal history to crystallization, defect ...
Md Tofazzal Hossain, Mohammed Intishar Nur, Md Shajedul Hoque Thakur, Indranil Dey, Md Mesbahul Maruf, Md Jahid Hasan, Suryasarathi Bose, Muhammad M. Rahman   +7 more
wiley   +1 more source

Disentangling Elemental Roles in an Amorphous Medium‐Entropy Electrocatalyst for Oxygen Evolution

Advanced Science, EarlyView.
An amorphous medium‐entropy FeCoNiMo‐a catalyst with a unique nanoring architecture is synthesized via a solvothermal method. The catalyst exhibits exceptional stability in anion exchange membrane water electrolysis, maintaining stable operation for over 600 h at 1 A cm−2.
Jinhu Wu, Xianjun Cao, Cheng Gong, Dongfang Li, Yaojie Lei, Daojin Zhou, Pengpeng Zhang, Zeliang Wu, Bin Yu, Xingwang Peng, Bernt Johannessen, Somnath Chanda Roy, Jinqiang Zhang, Hao Liu, Yufei Zhao   +14 more
wiley   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs

Advanced Science, EarlyView.
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang, Hui Wang, Hao Zhang, Zhenkuan Cao, Zehui Liu, Siying Li, Hongda Wang, Yuping Shan   +7 more
wiley   +1 more source

Reducing Ion Transport Friction by Mitigated Diluent‐Solvent Interaction for Sodium–Sulfur Battery

Advanced Science, EarlyView.
A local high‐concentration electrolyte to balance the ionic conductivity and interfacial stability is developed through replacing the high solvating DME with the moderate solvating diethyl ether to mitigate the diluent‐solvent interaction and reduce the local dynamic friction for Na+ transport, while maintaining the anion‐rich solvation clusters and ...
Sihang Xia, Jia Xu, Songling Wu, Shanshan Cao, Zhanju Wang, Xiangyang Gu, Jiang Liang, Kangning Zhao, Weina Xu, Chao Yang   +9 more
wiley   +1 more source

Predicting Single‐Cell Perturbation Responses Across Biological Contexts With a Deep Generative Model Integrating Optimal Transport

Advanced Science, EarlyView.
Single‐cell perturbation responses are predicted across held‐out biological contexts using scPILOT, a query‐conditioned two‐stage latent response‐transfer framework. A shared latent representation supports cell‐level response estimation by latent optimal transport, followed by Leiden‐localized query‐specific transfer and adaptive weighting.
Jialiang Wang, Ziqi Liu, Zhengqian Zhang, Yikun Cao, Junjun Ren, Peng Cheng, Jingjing Tian, Lingyun Xie, Xin Lu, Zhanwei Du, Yongzhuang Liu   +10 more
wiley   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Mechanically Reprogrammed Coaxial Fibers for Multiphysics Transduction and Human‐Machine Interfaces

Advanced Science, EarlyView.
A continuously wet‐spun coaxial fiber is developed to combine stretchable conductivity, resistive sensing, and self‐powered triboelectric sensing in a single architecture. A mechanically reprogrammed dual‐network sheath stabilizes large deformation and improves signal reliability. These fibers can be woven into textile interfaces for multichannel touch
Xinyi Cao, Chao Ye, Shengjie Ling, Ming Li, Zhao Sha, Chun‐Hui Wang, Shuhua Peng   +6 more
wiley   +1 more source