Results 231 to 240 of about 407,179 (246)

Medicina e Cirurgia de Animais de Companhia [PDF]

, 2015
Lara Sofia Loureiro Duarte
core  

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

[Corrigendum] Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy. [PDF]

Oncol Rep
Pan XW, Li L, Huang Y, Huang H, Xu DF, Gao Y, Chen L, Ren JZ, Cao JW, Hong Y, Cui XG.   +10 more
europepmc   +1 more source

Perfil Fenólico como Parâmetro de Distinção das Castas da Região do Dão [PDF]

, 2015
Ângela Sofia Carvalho Sousa
core  

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

The association between the red blood cell distribution width-to-albumin ratio and female infertility: A cross-sectional study. [PDF]

Medicine (Baltimore)
Yu Q, Cao Y.
europepmc   +1 more source

Retraction Note: Repression of LncRNA PART1 attenuates ovarian cancer cell viability, migration and invasion through the miR-503-5p/FOXK1 axis. [PDF]

BMC Cancer
Li B, Lou G, Zhang J, Cao N, Yu X.
europepmc   +1 more source

Cinco Casos Clínicos de Medicina e Cirurgia de Animais de Companhia [PDF]

, 2016
Mariana Matilde Antunes Vieira
core  

Case Report: Targeting the Achilles' heel of monomorphic epitheliotropic intestinal T-cell lymphoma. [PDF]

Front Oncol
Xue S, Gu HF, Yang F, Zhang W, Liu XY, Sun HP, Cao XY.   +6 more
europepmc   +1 more source