Results 271 to 280 of about 398,681 (296)

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

open access: yesAdvanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu   +13 more
wiley   +1 more source

Author Correction: Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis. [PDF]

open access: yesBone Res
Tu M   +12 more
europepmc   +1 more source

Rangeliose em cão doméstico (Canis lúpus familiaris ): uma doença emergente

open access: green, 2015
E. C. Silva   +10 more
openalex   +1 more source

Carcinoma de células renais sólido em cão

open access: diamond
Lara Moreira Feitosa de Alencar Santos   +3 more
openalex   +2 more sources

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

open access: yesAdvanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li   +12 more
wiley   +1 more source

Tromboembolismo pulmonar secundário a anemia hemolítica imunomediada em um cão com leptospirose – relato de caso.

open access: green, 2013
Bruno Alberigi   +4 more
openalex   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

open access: yesAdvanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang   +12 more
wiley   +1 more source

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