Results 91 to 100 of about 1,168,282 (300)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
El rol de la mujer ejecutiva en empresas locales que realizan negocios internacionales
Fórum Empresarial, 1999 Sinopsis de las siguientes tesis: Evaluación empírica de la habilidad de la ganancia calculada y del flujo de efectivo para predecir flujos futuros de efectivo, El rol de la mujer ejecutiva en empresas locales que realizan negocios internacionales, La ...
Celinés Nieves Colón
doaj +1 more source
Colite isquémica: fatores de risco, diagnóstico e prognóstico, em doentes submetidos a cirurgia [PDF]
, 1887 Berthelot Marcellin. Arrêté fixant la date de l'ouverture de la session d'examen pour les bourses des lycées et collèges de garçons. In: Bulletin administratif de l'instruction publique. Tome 41 n°738, 1887.
Sara Francisca Ferreira Fernandes
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
A atividade anticancerígena das ciclodextrinas : realidade ou ficção? [PDF]
, 2016 Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de CoimbraAs ciclodextrinas (CDs) poderão ser encaradas como valiosas ferramentas ...
Macedo, Ana Mafalda Brandão
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Patterns of metastasis in colon and rectal cancer
Scientific Reports, 2016 Investigating epidemiology of metastatic colon and rectal cancer is challenging, because cancer registries seldom record metastatic sites. We used a population based approach to assess metastatic spread in colon and rectal cancers.
M. Riihimäki +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Isolamento, identificação e caracterização das substâncias de Rapanea guianensis Aubl. (Myrsinaceae) e Diospyros hispida A. DC. (Ebenaceae) inibidoras de células de câncer [PDF]
, 2017 Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médicas, 2017.Texto parcialmente liberado pelo autor.
Dusi, Renata Garcia
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source