A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du +18 more
wiley +1 more source
Salvador Pérez Arroyo. Escritos de un arquitecto
Alegría Colón Mur
doaj
Intestinal tuberculosis mimicking Crohn's disease with ascending colon sinus tract: a case report. [PDF]
Lin Y, Hu X.
europepmc +1 more source
AI‐Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue
A fully integrated vibration‐assisted capsule is presented for the minimally invasive detection of bowel lesions. The capsule incorporates a wireless sensor and an eccentric motor to probe tissue mechanics in situ. By coupling triaxial vibration signals with AI‐based classification and analytical modeling, the system enables early, non‐visual ...
Xizheng Fang +6 more
wiley +1 more source
Discordance between radiological and pathological response to neoadjuvant immunotherapy in mismatch repair-deficient/microsatellite instability-high colorectal cancer: a meta-analysis. [PDF]
Xie Y, Liao L, Ding P, Jiang W.
europepmc +1 more source
Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge +14 more
wiley +1 more source
ARID3A Dysregulation Drives Colon Cancer Progression and Enhances Responsiveness to Aspirin. [PDF]
Li J +8 more
europepmc +1 more source
His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li +13 more
wiley +1 more source
Exploratory Proteomic Profiling Reveals Potential Mediators of 5-FU Response under p53 Deficiency in Colon Cancer Cells. [PDF]
Lee S, Lee J, Lee GS, Moon JH, Jung J.
europepmc +1 more source

