Results 131 to 140 of about 5,231,656 (248)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Aging, Dauer, and Stature Phenotypes Are Conferred by Structure-Directed Missense Mutations in the Endogenous AGE-1/Phosphatidylinositol 3-Kinase Catalytic Subunit. [PDF]

Aging Cell
Wu Y, Duong T, Rasmussen NR, Rossman KL, Reiner DJ.   +4 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Correction: Exposure of HL-60 human leukaemic cells to 4-hydroxynonenal promotes the formation of adduct(s) with α-enolase devoid of plasminogen binding activity. [PDF]

Biochem J
Barrera G, Gentile F, Pizzimenti S, Arcaro A, Pettazzoni P, Minelli R, D'Angelo D, Mamone G, Ferranti P, Toaldo C, Cetrangolo G, Formisano S, Dianzani MU, Uchida K, Dianzani C.   +14 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Mechanistic insights into interfacial failure of hard carbon anodes in sodium-ion batteries under extreme conditions. [PDF]

Chem Sci
Feng R, Wang Q, Wu X, Zhang H, Gao Y, Zhao N, Li J, Zhao X, Hu X.   +8 more
europepmc   +1 more source

Optimization of the liquid–liquid interfacial precipitation method for the synthesis of $$\hbox {C}_{60}$$ C 60 nanotubes

Bulletin of Materials Science, 2018
Dorra Mahdaoui, Chika Hirata, Nabil Omri, Takatsugu Wakahara, Manef Abderrabba, Kun’ichi Miyazawa   +5 more
openaire   +2 more sources

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

LAMP-Based Detection of <i>Candida albicans</i>: A Potential Tool for Candidemia Diagnosis. [PDF]

Can J Infect Dis Med Microbiol
Prompunt E, Jamnai K, Marome N, Phutthawong N, Sumphanapai T, Kamseng P, Kloypan C, Saoin S, Khamchun S, Nangola S.   +9 more
europepmc   +1 more source