Results 111 to 120 of about 24,082,670 (324)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

C-Band and O-Band Silicon Photonic Based Low-Power Variable Optical Attenuators

IEEE Photonics Journal, 2019
We propose and experimentally demonstrate low-power and broadband variable optical attenuators (VOAs) on the silicon photonics platform. The VOAs are based on a Mach–Zehnder interferometer structure.
Eslam El-Fiky, Maxime Jacques, Alireza Samani, Luhua Xu, Md. Ghulam Saber, David V. Plant   +5 more
doaj   +1 more source

Comparison of ship wake detectability on C-band and X-band SAR

, 2018
This article describes how a detectability model can be trained in the form of a binary classifier from a data set of synthetic aperture radar (SAR) images of ship wakes, augmented by automatic identification system data.
B. Tings, D. Velotto
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Design of C-band 9 MeV Small Focus Standing Wave Electron Linear Accelerating Structure

Yuanzineng kexue jishu
With the development of microwave technology, accelerators have become an indispensable part of scientific research and daily applications gradually, it has been used in many fields, such as medical radiotherapy, radiation sterilization, industrial ...
LI Shilin, YANG Jinghe, FAN Yuxuan, WANG Bo, YANG Yu, LEI Han
doaj   +1 more source

Comparison of the Optical Amplifiers EDFA and SOA Based on the BER and -Factor in C-Band

, 2017
Currently it is not possible to create a fully optical communication system without a software tool which simulates an optical communication line in real conditions prior to its construction.
T. Ivaniga, P. Ivaniga
semanticscholar   +1 more source

Efficient polarisation-preserving frequency conversion from a trapped-ion-compatible wavelength to the telecom C band

, 2017
We demonstrate polarisation-preserving frequency conversion of single-photon-level light at 854 nm, resonant with a trapped-ion transition and qubit, to the 1550-nm telecom C band. A total photon in / fiber-coupled photon out efficiency of $\sim$ 30 % is
Krutyanskiy, V., Lanyon, B. P., Meraner, M., Schupp, J.   +3 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source