Results 41 to 50 of about 177,948 (265)

Total Mapping Toolbox (TOMATO): An open source library for cardiac magnetic resonance parametric mapping

open access: yesSoftwareX, 2020
TOMATO (Total Mapping Toolbox) is a C++ library for the calculation of parametric maps in cardiac magnetic resonance imaging (MRI). As an open source project, TOMATO allows transparent and standardised cardiac longitudinal relaxation time (T1) mapping in
Konrad Werys   +12 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Resolving Structural Ambiguity in English Relative Clauses and Prepositional Phrases

open access: yesJournal of Languages and Language Teaching
Structural ambiguity remains a persistent challenge in English comprehension, particularly when relative clauses (RCs) and prepositional phrases (PPs) admit multiple interpretations.
Irfan Hamonangan Tarihoran   +2 more
doaj   +1 more source

State position on the existing contradictions of operational staff as governing body of modern regional law enforcement forces

open access: yesТеорія і практика правознавства, 2016
We consider the contradictions existing state position on the use of the operations staff as the governing body of modern regional law enforcement forces and trends in substance to overcome them are the following: a) the essence contradictions that arise
Микола Михайлович Орлов
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Ultrasound-guided fluid resuscitation versus usual care guided fluid resuscitation in patients with septic shock: a systematic review and meta-analysis

open access: yesEmergency and Critical Care Medicine
. Background. Ultrasound is widely used in critical care for fluid resuscitation in critically ill patients. We conducted a systematic review to assess the relationship between ultrasound-guided fluid resuscitation strategies and usual care in septic ...
Zheyuan Chen   +6 more
doaj   +1 more source

deal2lkit: A toolkit library for high performance programming in deal.II

open access: yesSoftwareX, 2018
We propose a software design for the efficient and flexible handling of the building blocks used in high performance finite element simulations, through the pervasive use of parameters (parsed through parameter files).
Alberto Sartori   +3 more
doaj   +1 more source

Object attraction and the role of structural hierarchy: Evidence from Persian

open access: yesGlossa, 2020
Research on subject-verb agreement production in SVO languages has shown that objects moved pre-verbally sometimes trigger attraction, i.e., erroneous agreement of the verb with the object rather than the subject.
Arsalan Kahnemuyipour   +2 more
doaj   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

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