Results 91 to 100 of about 23,038 (267)

Understanding trends in C–H bond activation in heterogeneous catalysis [PDF]

, 2018
A universal descriptor for the prediction of C–H bond activation barriers has been established, and combined with a thermodynamic analysis of methane activation, to provide design rules for various types of heterogeneous ...
Yoo, Jong Suk, Abild-Pedersen, Frank, Studt, Felix, Aljama, Hassan, Tsai, Charlie, Kulkarni, Ambarish R, Latimer, Allegra A, Nørskov, Jens K, Montoya, Joseph H   +8 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation

Molecules, 2015
Transition metal-catalyzed modifications of the activated heterocyclic bases of nucleosides as well as DNA or RNA fragments employing traditional cross-coupling methods have been well-established in nucleic acid chemistry.
Yong Liang, Stanislaw F. Wnuk
doaj   +1 more source

Natural Product Synthesis by C-H Activation

, 2018
The widespread use of transition-metal-mediated C-H bond activation has altered the field of organic synthesis. Notwithstanding the immense effect this strategy has had on classical organic reactions, the applications of this methodology extend further ...
MAITI, D, SINHA, SK, ZANONI, G
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Recent advances in electrochemical C–N bond formation via C–H/N–H activation with hydrogen evolution

Current Research in Green and Sustainable Chemistry
Electroorganic synthesis is a powerful sustainable tool for achieving greener and more efficient chemical processes across various industries. By adhering to the principles of green chemistry, atom economy, and resource efficiency, electroorganic ...
Subban Kathiravan, Ian A. Nicholls
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

C(sp3)–H trifluoromethylation of pyrrolidine by [W10O32]4−/copper synergetic photocatalysis: Theoretical investigation of reactivity and regioselectivity

Polyoxometalates
Polyoxometalates (POMs) are known for their well-established catalytic properties, particularly in photocatalysis, and have made significant strides in achieving selective C(sp3)−H functionalization.
Yu-Jiao Dong, Zhong-Min Su, Wei Guan
doaj   +1 more source

Photosensitized direct C–H fluorination and trifluoromethylation in organic synthesis

Beilstein Journal of Organic Chemistry, 2020
The importance of fluorinated products in pharmaceutical and medicinal chemistry has necessitated the development of synthetic fluorination methods, of which direct C–H fluorination is among the most powerful.
Shahboz Yakubov, Joshua P. Barham
doaj   +1 more source

Radical-Mediated C-H Bond Activation

, 2015
Dr. Azman\u27s Contribution to Li, J. J. (2015). C-H bond activation in organic synthesis.
Adam Azman, Azman, Adam M.
core   +1 more source