Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Beyond enterprise resource planning projects: innovative strategies for competitive advantage [PDF]
A rapidly changing business environment and legacy IT problems has resulted in many organisations implementing standard package solutions. This 'common systems' approach establishes a common IT and business process infrastructure within organisations and
Holland, C, Kawalek, P, Light, BA
core +1 more source
Radiative Properties of Pair-instability Supernova Explosions
We present non-LTE time-dependent radiative-transfer simulations of pair-instability supernovae (PISNe) stemming from red-supergiant (RSG), blue-supergiant (BSG) and Wolf-Rayet (WR) star rotation-free progenitors born in the mass range 160-230Msun, at 10^
Blondin, Stéphane +4 more
core +3 more sources
Light fragments from (C + Be) interactions at 0.6 GeV/nucleon
Nuclear fragments emitted at 3.5° in 12C fragmentation at 0.6 GeV/nucleon have been measured. The spectra obtained are used for testing the predictions of four ion-ion interaction models: INCL++, BC, LAQGSM03.03 and QMD as well as for the comparison with
Abramov B.M. +12 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Dynamics of carbon dioxide exchange of a wheat community grown in a semi-closed environment [PDF]
A wheat (Triticum aestivum Yecora Rojo) community was grown in the semi-closed conditions of the NASA/KSC Biomass Production Chamber (BPC). Experiments were conducted to determine whole community carbon dioxide exchange rates as influenced by growth and ...
Corey, Kenneth A.
core +1 more source
Visible light-driven C−H activation and C–C coupling of methanol into ethylene glycol
Direct transformation of methanol into two- or multi-carbon compounds is extremely attractive but remains a challenge. Here, the authors report an efficient photocatalytic route to the transformation of methanol into ethylene glycol and hydrogen over a ...
Shunji Xie +10 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Monitoring-Oriented Programming: A Tool-Supported Methodology for Higher Quality Object-Oriented Software [PDF]
This paper presents a tool-supported methodological paradigm for object-oriented software development, called monitoring-oriented programming and abbreviated MOP, in which runtime monitoring is a basic software design principle.
Chen, Feng +2 more
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source

