Results 131 to 140 of about 21,258,464 (294)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evaluation of Electro-Optic Behaviour of Chiral Smetic Liquid Crystals Dispalys with V-shaped response [PDF]

open access: yes, 2003
In the last years, chiral smectic liquid crystals with V-shaped electro-optic response have been reported as one of the most promising technologies for display applications.
Urruchi del Pozo, Virginia   +3 more
core   +1 more source

Numerical models of three typical shaped collapse column along mining trend.

open access: yes, 2019
(A) Inverted funnel shaped. (B) Columnar shaped. (C) Funnel shaped.
Zijie Hong (7140272)   +6 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Beam based alignment of C-shaped quadrupole magnets [PDF]

open access: yes, 1998
Many storage rings have implemented a method of finding the positional offset between the electrical center of the beam position monitors (BPM) and the magnetic center of the adjacent quadrupole magnets.
Portmann, G., Robin, D.
core  

Structural characterization of the 'lantern-shaped' platinum(III) complex [Pt2Cl2{N(H)C(Bu-t)O}(4)]

open access: yes, 2002
The synthesis of a new platinum(III) 'lantern-shaped' complex with amidate bridging ligands, [Pt2Cl2{N(H)C(Bu-t)O}(4)] (1), is described. Complex I has been structurally characterized by X-ray diffraction and compared with the related compound [Pt2I2{N(H)
A. DOLMELLA   +9 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Prevalence of C-shaped canals in mandibular second molars in a Kerman population

open access: yesمجله دانشکده دندانپزشکی اصفهان, 2011
Introduction: Knowledge of the possible internal anatomy and morphology of the root canal system of the teeth is a key factor in successful root canal treatment.
Maryam Kuzekanani, Malek Bahmani
doaj  

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

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