Results 111 to 120 of about 20,673,683 (288)

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Assessment of C-Shaped Canal Morphology in Mandibular and Maxillary Second Molars in an Iraqi Subpopulation Using Cone-Beam Computed Tomography. [PDF]

Scanning, 2022
Abdalrahman K, Talabani R, Kazzaz S, Babarasul D.   +3 more
europepmc   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

Root and canal morphology of mandibular second molars in a Chinese Kazakh population by cone-beam computed tomography

BMC Oral Health
Objective This study aimed to investigate variations in root and canal morphology of the mandibular second molars in a Chinese Kazakh population using cone-beam computed tomography (CBCT). Methods A total of 374 mandibular second molars from 236 patients
Shuchun Yang, Chenye Li, Hui Shi, Ming Liu, Xu Wang   +4 more
doaj   +1 more source

The C-shaped Canal System in Mandibular Molars of a Saudi Arabian Population: Prevalence and Root Canal Configurations Using Cone-Beam Computed Tomography. [PDF]

Cureus, 2022
Alnowailaty Y, Alghamdi F.
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

C-shaped Canal System in Maxillary Molars Evaluated by Cone- Beam Computed Tomography in an Argentine subpopulation. [PDF]

Acta Odontol Latinoam, 2022
Chaintiou Piorno R, Consoli Lizzi EP, Gualtieri AF, Rodríguez PA.   +3 more
europepmc   +1 more source

Root Canal Obturation Quality in 3D-Printed C-Shaped Canals with Different Filling Techniques

Acta stomatologica Croatica : International journal of oral sciences and dental medicine
This study aimed to assess the quality of canal obturation in 3D-printed C-shaped canals using Micro-CT and dye penetration with different filling techniques.Sixty 3D-printed teeth with C-shaped canals were obturated using: AH Plus with continuous wave (AHCW), iRoot SP with single cone (SPSC) and iRoot SP with continuous wave (SPCW).
Fu, Di, Li, Yanyao, Wang, Yuwei, Yao, Lin, Zhou, Ge, Zhu, Yunwo, Zou, Ling   +6 more
openaire   +3 more sources

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source