Results 51 to 60 of about 21,365,185 (276)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Prevalence of C-shaped root canal in a Brazilian subpopulation: a cone-beam computed tomography analysis [PDF]

, 2014
The aim of this study was to use cone-beam computed tomography (CBCT) images to evaluate the prevalence and configurations of C-shaped canals in permanent mandibular second molars among members of a Brazilian subpopulation.
Solange Maria Almeida, Deborah Queiroz Freitas, Ladeira, Daniela Brait Silva, Almeida, Solange Maria, Freitas, Deborah Queiroz, Daniela Brait Silva Ladeira, Cruz, Adriana Dibo, Adriana Dibo Cruz   +7 more
core   +2 more sources

Management of c-shape root canal configuration: Case reports

IP Indian Journal of Conservative and Endodontics, 2020
Unusual root canal anatomy always poses a diagnostic and treatment challenge.Therefore a thorough knowledge of root canal anatomical variations along with proper diagnosis, treatment planning and clinical expertise is the key to their successful management.
Nirmala Bishnoi, Ida de Noronha de Ataide, Marina Fernandes, Rajan Lambor, Bobbin Sandhu   +4 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Biometric Analysis of C-shaped Root Canals in Mandibular Second Molars Using Cone-Beam Computed Tomography [PDF]

, 2018
Introduction: The configuration of C-shaped root canals, root canal wall thickness and orientation of the thinnest area using CBCT in mandibular second molars were assessed.  Methods and Materials: Seventy five CBCT scans were evaluated.
Sheikhi, Mahnaz, Riazifar, Negin, Zangouyi Boushehri, Maryam, Karamifar, Kasra, Amini, Kamal   +4 more
core   +1 more source

Prevalence and morphology of C-shaped and non-C-shaped root canal systems in mandibular second molars

, 2022
BACKGROUND: There are no cone-beam computed tomography (CBCT)-based data on the anatomy of mandibular second molars in an Australian population. This study investigated the prevalence and descending morphology of mandibular second molars with and without
Fenelon, T, Parashos, P
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Root canal configuration and the prevalence of C-shaped canals in mandibular second molars in an Iranian population

Journal of Oral Science, 2008
A total of 139 extracted mandibular second molars were injected with India ink and demineralized. They were made clear and transparent with methyl salicylate, and the anatomy of their canals was studied. It was found that 86.3% of mandibular second molars had two roots, 9.3% had one root, and 4.3% had three roots.
Rahimi, Saeed, Shahi, Shahriar, Lotfi, Mehrdad, Zand, Vahid, Abdolrahimi, Majid, Es'haghi, Reza   +5 more
openaire   +3 more sources