Results 331 to 340 of about 168,641 (363)

C‐type natriuretic peptide in prostate cancer

APMIS, 2009
C‐type natriuretic peptide (CNP) is expressed in the male reproductive organs in pigs. To examine whether the human prostate also expresses the CNP gene, we measured CNP and N‐terminal proCNP in prostate cancer tissue extracts and performed immunohistochemical biopsy staining.
Nielsen, Soeren Junge, Iversen, Peter, Rehfeld, Jens F., Jensen, Helle Lone, Goetze, Jens Peter   +4 more
openaire   +4 more sources

C-type natriuretic peptide: a selective cardiovascular peptide

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1993
Studies were performed in three groups of anesthetized dogs to compare the structurally related peptides atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Group 1 (n = 5) and group 2 (n = 4) received intravenous infusions of CNP or ANP respectively at doses of 10 ng.kg-1.min-1 and 100 ng.kg-1.min-1.
Denise M. Heublein, Chi-Ming Wei, John C. Burnett, Alfredo L. Clavell, A. J. Stingo   +4 more
openaire   +3 more sources

Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure

Circulation, 2018
Background: Peripheral vascular resistance has a major impact on arterial blood pressure levels. Endothelial C-type natriuretic peptide (CNP) participates in the local regulation of vascular tone, but the target cells remain controversial.
K. Špiranec, W. Chen, F. Werner, V. Nikolaev, T. Naruke, F. Koch, A. Werner, Petra Eder-Negrin, Rodrigo Diéguez-Hurtado, R. Adams, H. Baba, H. Schmidt, K. Schuh, B. Skryabin, K. Movahedi, F. Schweda, M. Kuhn   +16 more
semanticscholar   +1 more source

TransCon CNP, a Sustained-Release C-Type Natriuretic Peptide Prodrug, a Potentially Safe and Efficacious New Therapeutic Modality for the Treatment of Comorbidities Associated with Fibroblast Growth Factor Receptor 3–Related Skeletal Dysplasias

Journal of Pharmacology and Experimental Therapeutics, 2019
TransCon CNP is a C-type natriuretic peptide (CNP-38) conjugated via a cleavable linker to a polyethylene glycol carrier molecule, designed to provide sustained systemic CNP levels upon weekly subcutaneous administration.
V. Breinholt, C. E. Rasmussen, P. Mygind, M. Kjelgaard‐Hansen, Frank Faltinger, Ana Bernhard, J. Zettler, U. Hersel   +7 more
semanticscholar   +1 more source

C-Type Natriuretic Peptide and Overgrowth

2009
Natriuretic peptides are a family of structurally related peptides with different distinct biological effects. C-type natriuretic peptide (CNP)-mediated signaling is important for endochondral ossification and intervenes in the control of chondrocyte maturation by regulating the balance between proliferation and terminal differentiation. CNP is encoded
BOCCIARDI, RENATA, RAVAZZOLO, ROBERTO
openaire   +4 more sources

Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension

Journal of Hypertension, 1994
To study the relationship between hypertension and the plasma levels of brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and to determine whether the plasma levels of BNP and CNP are correlated.A cross-sectional study of the plasma levels of BNP and CNP in hypertensive patients and normotensive controls matched for age and sex was ...
Brown, MJ, Cheung, BM
openaire   +4 more sources

C-type natriuretic peptide and atrial natriuretic peptide receptors of rat brain

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1993
Natriuretic peptide receptors in rat brain were mapped by in vitro autoradiography using 125I-labeled [Tyr0]CNP-(1-22) to bind atrial natriuretic peptide receptor (ANPR)-B and ANPR-C receptors selectively, and 125I-labeled alpha-ANP to select ANPR-A and ANPR-C receptors.
Zhiyi Zuo, John Brown
openaire   +3 more sources

N-terminal pro-C-type natriuretic peptide, but not C-type natriuretic peptide, is greatly elevated in the fetal circulation

Clinical Science, 2004
We have identified recently a new peptide, NT-proCNP(1–50) (N-terminal pro-C-type natriuretic peptide), in the circulation of humans and sheep. A previous report of an elevated fetal–maternal gradient in immunoreactive CNP raised the possibility that processing and metabolism of proCNP may differ in maternal and fetal tissues.
Eric A. Espiner, Risto Kaaja, Timothy C. R. Prickett, M. Gary Nicholls, Timothy G. Yandle, A. Mark Richards   +5 more
openaire   +3 more sources

C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid

Brain Research, 1993
In order to investigate whether C-type natriuretic peptide (CNP) is present in human cerebrospinal fluid (CSF), we measured CNP-like immunoreactivity (-LI) in human CSF by specific radioimmunoassay (RIA) for CNP. We also measured atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations in human CSF. ANP-LI, BNP-LI, and CNP-LI
Izumi Nagata, Norio Hama, Osamu Hirai, Shin Ichi Suga, Osamu Nakagawa, Susumu Miyamoto, Takaaki Kaneko, Hiroo Imura, Gotaro Shirakami, Hiroaki Kubo, Haruhiko Kikuchi, Kazuwa Nakao   +11 more
openaire   +3 more sources

Role of natriuretic peptide clearance receptor in in vivo control of C-type natriuretic peptide

American Journal of Physiology-Heart and Circulatory Physiology, 1995
C-type natriuretic peptide (CNP) is a newly described 22-amino acid peptide of endothelial cell origin, which has selective cardiovascular actions and is structurally related to atrial natriuretic peptide (ANP). Recent in vitro studies have demonstrated that an important regulatory pathway for the clearance of natriuretic peptides involves binding to ...
Roland R. Brandt, John C. Burnett, J. A. Lewicki, Denise M. Heublein, Lawrence L. Aarhus   +4 more
openaire   +3 more sources