Retracing the path of evolution: polymorphisms of <i>aspA</i> codon 363 shape the fitness of <i>Yersinia pestis</i>. [PDF]
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The Hippo kinases MST1/2 integrate sterile and infectious signals to regulate macrophage cell death. [PDF]
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Dietary methionine mitigates immune-mediated damage by enhancing renal clearance of cytokines. [PDF]
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RIOK2 kinase regulates the translocation of the FADD-RIPK1-Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis. [PDF]
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<i>Yersinia pseudotuberculosis</i> and <i>Y. enterocolitica</i> abortions in sheep and goats in California: a series of cases diagnosed at CAHFS laboratories, 2002-2023. [PDF]
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Occurrence and Monitoring of the Zoonotic Pathogen <i>Yersinia pseudotuberculosis</i> in Various Zoo Animal Species. [PDF]
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Corynebacterium pseudotuberculosis, a facultative intracellular bacterium, is an important zoonotic pathogen responsible for chronic inflammatory diseases. TRIM21, an E3 ubiquitin-protein ligase, plays pivotal roles in inflammation regulation. However, its role during C. pseudotuberculosis infection is unclear. Here, we found that TRIM21 expression was
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C. pseudotuberculosis Phop confers virulence and may be targeted by natural compounds
Integr. Biol., 2014The bacterial two-component system (TCS) regulates genes that are crucial for virulence in several pathogens. One of such TCS, the PhoPR system, consisting of a transmembrane sensory histidine kinase protein (PhoR) and an intracellular response regulator protein (PhoP), has been reported to have a major role in mycobacterial pathogenesis.
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