Results 11 to 20 of about 8,778 (181)

The comparison of two pendrin inhibitors, YS-01 and PDSinh-C01, in lipopolysaccharide-induced acute lung injury [PDF]

Scientific Reports
Acute respiratory distress syndrome (ARDS) is a life-threatening condition without specific treatments, relying on mechanical ventilation and supportive care.
Hyeon Kyu Choi, Ji Young Son, Mi Hwa Shin, Jinhong Park, Doona Song, Young-Min Hyun, Ji-Hwan Ryu, Je Kyung Seong, Gyoonhee Han, Wan Namkung, Chul Hoon Kim, Jae Young Choi, Moo Suk Park   +12 more
doaj   +2 more sources

Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses [PDF]

Nature Communications
Overactivation of FcγRI by immune complexes (IC) is implicated in various autoimmune disorders and neuropathies. Currently, no effective FcγRI-specific blocking antibodies are available. Here we report preclinical data revealing two anti-FcγRI antibodies,
Tosca Holtrop, Arianne M. Brandsma, Louris J. Feitsma, Steffen Krohn, Petra Moerer, Frederique van den Haak, Anouk Versnel, Leonie Voss, Elsemieke M. Passchier, Maaike Nederend, J. H. Marco Jansen, Anouk G. van Mourik, Rolf T. Urbanus, Diane van der Woude, Roger E. G. Schutgens, Rene E. M. Toes, Bert J. C. Janssen, Anja Lux, Kevin Budding, Matthias Peipp, Jeanette H. W. Leusen   +20 more
doaj   +2 more sources

Intravitreal Gene Therapy with LX102-C01 in Neovascular Age-Related Macular Degeneration: A Phase I Dose-Escalation Study of 12-Month Safety and Efficacy Outcomes [PDF]

Ophthalmology Science
Purpose: To assess the safety, tolerability, and preliminary efficacy of a single intravitreal injection of LX102-C01 in eyes with neovascular age-related macular degeneration (nAMD) followed up to 52 weeks.
Junran Sun, Mengxi Shen, Jieqiong Chen, Yidong Wu, Yanping Zhou, Jingyang Feng, Yuxuan Cheng, Huixun Jia, Xiaolu Yang, YuanYuan Gong, Yang Liu, Hong Wang, Ruikang K. Wang, Philip J. Rosenfeld, Tong Li, Fenghua Wang, Xiaodong Sun   +16 more
doaj   +2 more sources

Integrated Single-Cell and TCR Profiling Reveals Protection-Associated CD8⁺ T Cell Subsets Linked to Viral Control in PRRSV. [PDF]

Adv Sci (Weinh)
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Kong C, Chen S, Li M, Wang M, Zhang H, Zhou B, Xie Z, Wang C, Gao P, Luo J, Yang H, Chen R, Zhang D, Li J, Han J.   +14 more
europepmc   +2 more sources

Shaping Development Through Parents: A Scalable Approach to Early Learning. [PDF]

Dev Sci
ABSTRACT Early childhood is a sensitive period for cognitive, language, and socio‐emotional development, with parental engagement playing a central role. In Argentina, families facing socioeconomic adversity often encounter barriers that limit access to developmentally enriching parent–child activities; heightening developmental risk amid ongoing ...
Nayeli GG, Eugenia NC, Fiona T, Roxana S, Claudia V, Alexandra H.   +5 more
europepmc   +2 more sources

Epinephrine Affects Ribosomes, Cell Division, and Catabolic Processes in Micrococcus luteus Skin Strain C01: Revelation of the Conditionally Extensive Hormone Effect Using Orbitrap Mass Spectrometry and Proteomic Analysis

Microorganisms, 2023
In the current study, extensive Orbitrap mass spectrometry analysis was conducted for skin strain Micrococcus luteus C01 planktonic cultures and biofilms after 24 h and 72 h of incubation either in the presence of epinephrine or without any ...
Andrei V. Gannesen, Rustam H. Ziganshin, Maria A. Ovcharova, Ekaterina D. Nevolina, Alena I. Klimko, Sergey V. Martyanov, Vladimir K. Plakunov   +6 more
doaj   +1 more source

Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1G2032R and ALKG1202R

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Clinical treatment by FDA-approved ROS1/ALK inhibitor Crizotinib significantly improved the therapeutic outcomes. However, the emergence of drug resistance, especially driven by acquired mutations, have become an inevitable problem and worsened the ...
Siming Liu, Chuan Huang, Chunhui Huang, Yaqi Huang, Yonghuan Yu, Guowu Wu, Fengqiu Guo, Ying Jiang, Shanhe Wan, Zhengguang Zhu, Yuanxin Tian, Jianghua Zhu, Jiajie Zhang   +12 more
doaj   +1 more source

Natural product nanofibers derived from Trichoderma hamatum K01 to control citrus anthracnose caused by Colletotrichum gloeosporioides

Open Agriculture, 2023
The antifungal activity of Trichoderma hamatum K01 to control Colletotrichum gloeosporioides C01 was recorded. Pathogenicity of C. gloeosporioides C01 on citrus leaves was confirmed by the Koch postulate. T.
Phal Pheaktra, Soytong Kasem, Poeaim Supattra   +2 more
doaj   +1 more source

Molecular marking in breeding Brassica oleracea L. for resistance to Xanthomonas campestris pv. campestris [PDF]

E3S Web of Conferences, 2021
In the presented study, we have studied polymorphism of 30 microsatellite loci in terms of resistance to black rot (Xanthomonas campestris). Three SSR markers (Ol10-C01, Ol11-H06, BoESSR 726) were identified, showing polymorphism in white cabbage forms ...
Makukha Yuliya, Dubina Elena
doaj   +1 more source

Impact of energy innovations on the Ukraine’s economy: Strategic direction and managerial practices

ECONOMICS, 2022
Diversification of energy sources and innovative development of the energy sector are one of the main directions for ensuring sustainable development and decarbonization of the economy.
Trofymenko Olena, Ilyash Olha, Voitko Serhii, Dluhopolska Tetiana, Kozlovskyi Serhii, Hrynkevych Svitlana   +5 more
doaj   +1 more source