Bispecific NK‐Cell Engager Targeting TP53 Mutation Through Integration of a TCR‐mimic Antibody [PDF]
MedComm (2020)Most existing NK cell engagers (NKCEs) target tumor‐associated antigens (TAAs), risking on‐target, off‐tumor toxicity. We engineered a novel NKCE termed C33×CD16, a single‐chain diabody (scDb) constructed by fusing TCR‐mimic antibody C33‐Ab (targeting p53R175H/HLA‐A*02:01) to the scFv of 3G8 (anti‐CD16 antibody) (a).
Wu H +16 more
europepmc +2 more sources
Obesity Impairs Cognitive Function with No Effects on Anxiety-like Behaviour in Zebrafish [Dataset]
, 2023 Growth parameters: Body weight (BW), length (BL), and body mass index (BMI) after overfeeding in zebrafish Total lipid levels after zebrafish overfeeding Brain Monoamine quantification after overfeeding in zebrafish Anxiety-like behavior ...
Cerdá-Reverter, José Miguel
core +1 more source
Unveiling the probiotic potential of the anaerobic bacterium cetobacterium sp. nov. C33 for enhancing nile tilapia (oreochromis niloticus) cultures [PDF]
, 2023 9 páginasLa cepa bacteriana Cetobacterium sp. C33 fue aislada del contenido microbiano intestinal de tilapia del Nilo ( O . niloticus ) bajo condiciones anaeróbicas.
Rodriguez, Jorge Alberto +4 more
core +1 more source
Simulation of hydrogen permeation through pure iron for trapping and surface phenomena characterisation [PDF]
, 2020 The authors gratefully acknowledge financial support from the Ministry of Economy and Competitiveness of Spain through gran RTI2018-096070-B-C33. E. Martínez-Pañeda also acknowledges financial support from EPSRC funding under grant No.
Cuesta, I. I. +5 more
core +1 more source
Syntheses of C33-, C35-, and C39-Peridinin and Their Spectral Characteristics [PDF]
Organic Letters, 2009 Peridinin, a nor-carotenoid, exhibits an exceptionally high energy transfer efficiency to chlorophyll a in photosynthesis in the sea. This efficiency would be related to the unique structure of peridinin. To answer the question of why peridinin possesses the irregular C37 skeleton, we have achieved the synthesis of three peridinin derivatives.
Takayuki, Kajikawa +7 more
openaire +2 more sources
Hydraulic fracture behavior in the presence of hydrogen in notched miniature cylindrical specimens of a 42CrMo4 steel [PDF]
, 2022 The authors would like to thank the Spanish Government for the financial support received to perform the research projects RTI2018-096070-B-C33 and PID2021-124768OB-C21. L.B.
Cuesta, I. I. +5 more
core +1 more source
El Trimestre Económico, 2018 Introducción: Esta investigación examina la relación entre el uso de energía (UEN) y la formación bruta de capital (FBC) fijo con la tasa de crecimiento del producto interno bruto (PIB) en 73 países.
Héctor F. Salazar-Núñez +1 more
doaj +1 more source
Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor [PDF]
, 2015 Phosphodiesterase-9 (PDE9) inhibitors have been studied as potential therapeutics for treatment of central nervous system diseases and diabetes. Here, we report the discovery of a new category of PDE9 inhibitors by rational design on the basis of the ...
Liang, B. +12 more
core +1 more source
Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2020 After 1990, the problem of finding econometric models to assess the influence of economic development on the environment becomes a global goal, a central element of regional, national and Community policies.
Cosma Ioana Gabriela +4 more
doaj +1 more source
Molecular Basis of NPY Recognition and Ligand Selectivity at the Neuropeptide Y5 Receptor
Angewandte Chemie, EarlyView.Here, we present the first active structure of the neuropeptide Y5 receptor (NPY5R) in complex with its endogenous ligand NPY and the Gi1 protein. The cryo‐electron microscopy structure, validated by extensive mutagenesis studies, gives important insights into the molecular mechanisms underlying ligand binding and receptor activation.
Lisa Christin Peuker +8 more
wiley +2 more sources