Results 141 to 150 of about 5,460 (176)

Methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to epilepsy

Neurological Sciences, 2018
Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism was reported as risk factor for multiple diseases due to its role in conversion of homocysteine to methionine. The aim of the present meta-analysis was to find out the validity of association of C677T polymorphism with epilepsy susceptibility.Pubmed, Science Direct, Springer Link and ...
Vandana, Rai, Pradeep, Kumar
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Association of methylenetetrahydrofolate reductase (C677T) polymorphism with hyperuricemia

Nutrition, Metabolism and Cardiovascular Diseases, 2007
Homozygosity for the thermolabile variant of 5,10-methylene tetrahydrofolate reductase (C677T) has been suggested to be positively associated with the risk of vascular disease and neural tube defects. In addition, recent studies have suggested that elevated serum uric acid predicts ischemic heart disease, and epidemiological data on ethnic groups have ...
Jamal, Golbahar, Mohammad A, Aminzadeh, Qasim M, Al-Shboul, Salah, Kassab, Golam R, Rezaian   +4 more
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Biological and clinical implications of the MTHFR C677T polymorphism

Trends in Pharmacological Sciences, 2001
The enzyme methylenetetrahydrofolate reductase (MTHFR) directs folate species either to DNA synthesis or to homocysteine (Hcy) remethylation. The common MTHFR C677T polymorphism affects the activity of the enzyme and hence folate distribution. Under conditions of impaired folate status, the homozygous TT genotype has been regarded as harmful because it
P M, Ueland, S, Hustad, J, Schneede, H, Refsum, S E, Vollset   +4 more
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A Study of the MTHFR Gene Polymorphism C677T in Colorectal Cancer

Clinical Colorectal Cancer, 2009
The aim of this study was to examine the clinical significance of the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T in colorectal cancer (CRC). The hypothesis was that the genotype could affect the risk of cancer development and the results of cancer treatment.Genotyping was made for a random 30% (n = 544) of all patients treated ...
Kristoffer, Derwinger, Yvonne, Wettergren, Elisabeth, Odin, Göran, Carlsson, Bengt, Gustavsson   +4 more
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Methylenetetrahydrofolate Reductase C677T Genotype and Venous Thromboembolic Disease

Respiration, 2000
<i>Background:</i> Many studies have suggested an increased risk of venous thromboembolism (VTE) in patients with mild hyperhomocysteinemia. The C677T mutation in the MTHFR gene has recently been described as a cause of mild hyperhomocysteinemia.<i>Objectives:</i> To investigate the potential of the C677T mutation in the MTHFR ...
Couturaud, Francis, Oger, Emmanuel, Abalain, Jean-Hervé, Chenu, Eric, Guias, Bruno, Floch, H. H., Mercier, Bernard, Mottier, Dominique, Leroyer, Christophe   +8 more
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Maternal and neonatal MTHFR-C677T mutation: A case report

Journal of Pediatric Neurology, 2015
Homozygosis for the thermolabile variant (C677T) of the methylene-tetrahydropholate reductase (MTHFR) gene has been related to a high incidence of neural tube defects, pre-eclampsia, retardation in fetal growth and hyperhomocysteinemia. The latter represents a known risk factor for thrombosis. We report the case of a newborn with severe cerebral damage
PISANI, Francesco, SCARANO A.
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The influence of MTHFR C677T polymorphism in chronic lymphocytic leukemia

ELECTROPHORESIS, 2019
AbstractSome factors have been associated with the etiology of chronic lymphocytic leukemia (CLL), among them the Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism. The aim of this study was to evaluate the role of MTHFR C677T polymorphism in CLL.
Angela Adamski da Silva Reis, Keila Correia de Alcântara, Danielle Leão Cordeiro de Farias, Laura Raniere Borges dos Anjos, Débora Acyole Rodrigues, Gustavo Rodrigues Pedrino, Rodrigo da Silva Santos   +6 more
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MTHFR C677T polymorphism in chronic pancreatitis and pancreatic adenocarcinoma

Cell Biochemistry and Function, 2008
AbstractChronic pancreatitis and pancreatic adenocarcinoma are extensively studied as common and potentially lethal disorders. However, their causes and genetic background in most cases remain unclear. The C677T polymorphism in 5′,10′‐methylenetetrahydrofolate reductase (MTHFR) gene may modulate the risk of pancreatic disorders.
Nisević, Ivan, Dinić, Jelena, Nikolić, Aleksandra, Đorđević, Valentina, Lukić, Snežana, Ugljesić, Milenko, Anđelić-Jelić, Marina, Petrović-Stanojević, Nataša, Radojković, Dragica   +8 more
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The C677T methylenetetrahydrofolate reductase mutation is not associated with Alzheimer's disease

Neuroscience Letters, 2001
The methylenetetrahydrofolate reductase (MTHFR) gene has been recently considered as a candidate gene for Alzheimer's disease (AD). MTHFR is a key enzyme in the metabolism of homocysteine and elevated levels of that amino acid have been associated to Vascular Dementia and AD.
Brunelli T, BAGNOLI, SILVIA, GIUSTI, BETTI, NACMIAS, BENEDETTA, Pepe G, SORBI, SANDRO, Abbate R.   +6 more
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A meta‐analysis of the MTHFR C677T polymorphism and schizophrenia risk

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2005
AbstractEpigenetic mechanisms such as methylation of DNA, could lead to abnormal neurodevelopment and may be important in the etiology of schizophrenia. Maternal dietary folate intake may play a role in determining methylation levels. The MTHFR gene C677T polymorphism influences folate metabolism and intracellular availability of folate metabolites for
Lewis, Sarah J., Zammit, Stanley, Gunnell, David, Smith, George Davey   +3 more
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