Results 11 to 20 of about 3,418 (213)

Functional Characterization of ycao in Escherichia coli C91 Reveals Its Role in Siderophore Production, Iron-Limited Growth, and Antimicrobial Activity [PDF]

Antibiotics
Background: The emergence of antibiotic-resistant bacteria is one of the top health concerns. Escherichia coli is a Gram-negative bacterium that commonly causes severe infections. However, this research exposed its antibiotic-producing potential. Methods:
Khadijah M. Dashti, H. Ebrahim, Leila Vali, Ali A. Dashti   +3 more
doaj   +5 more sources

A Highly Selective GSK-3β Inhibitor CHIR99021 Promotes Osteogenesis by Activating Canonical and Autophagy-Mediated Wnt Signaling [PDF]

Frontiers in Endocrinology, 2022
The discovery and application of small molecules is one of the practical strategies of safe osteogenic drugs. The small molecule CHIR99021 (C91) is a highly specific, safe, and most effective GSK-3β Inhibitor.
Bo Wang, Saima Khan, Pengtao Wang, Xiaofang Wang, Yangxi Liu, Jingjing Chen, Xiaolin Tu   +6 more
doaj   +2 more sources

HTLV-1 Tax Reshapes the DNA-Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation. [PDF]

Cancer Sci
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Tosaka S, Mizuike J, Yano M, Uchimaru K, Yamagishi M.   +4 more
europepmc   +2 more sources

Lymphoma, multiple myeloma and leukaemia incidence in regions of Belarus most heavily contaminated by the Chernobyl accident. [PDF]

Int J Cancer
What's new? The 1986 Chernobyl accident led to widespread radioactive contamination across parts of Europe, with elevated childhood leukaemia rates observed in heavily affected areas of Ukraine. Data on long‐term haematological and other non‐thyroid cancer risk in the general population in heavily contaminated regions, however, remain limited.
Zupunski L, Yaumenenka A, Veyalkin I, Minenko V, Moiseyev P, Schüz J, Kukhta T, Trofimik S, Harbron R, Drozdovitch V, Ostroumova E.   +10 more
europepmc   +2 more sources

Prevalence of Cancer Survivors in 2019 Among Patients Diagnosed Between 1975 and 2019: A Population-Based Study in Japan. [PDF]

Cancer Med
Estimating Cancer Prevalence in Japan: Insights from the Osaka Cancer Registry ABSTRACT Owing to improved prognosis, cancer survivors are a growing population; however, little is known about their prevalence in Asian countries. This study estimated the prevalence and characteristics of cancer survivors in Japan, including long‐term survivors.
Kudo H, Nakata K, Kishimoto K, Ikawa T, Iwaki Y, Kuwabara Y, Morishima T, Miyashiro I.   +7 more
europepmc   +2 more sources

Cytotoxic Effects of a Triorganotin Derivative on HTLV-1-Infected Cells at Different Immortalization/Transformation Stages In Vitro [PDF]

Molecules
Among the metal-derived complexes, recently, tin derivatives have been investigated as promising anti-cancer drug candidates. Our previous study showed that the tin-based compound Bu3SnOCOCF3 (TBT) exerts cytotoxic activity on solid tumor cell lines.
Valeria Stefanizzi, Antonella Minutolo, Evariste Molimbou, Emanuela Balestrieri, Martina Giudice, Franca M. Cordero, Claudia Mosca, Antonio Mastino, Beatrice Macchi, Claudia Matteucci, Sandro Grelli, Francesca Marino-Merlo   +11 more
doaj   +2 more sources

Cancer Prevalence Among Large Cohort of Individuals With Down Syndrome: Implications for Screening Guidelines. [PDF]

Cancer Med
Individuals with Down syndrome have distinctive cancer profiles as compared with the general US population. Healthcare guidelines related to cancer screenings should reflect these unique profiles. ABSTRACT Introduction It is known that individuals with Down syndrome (DS) have a significantly different spectrum of malignancies and neoplasms.
Fitzpatrick V, Noah A, Rivelli A, Johnson R, Zak M, Espinosa J, Chicoine B.   +6 more
europepmc   +2 more sources

m⁶A RNA Modification Controls HTLV-1 Tax and Host Gene Expression. [PDF]

Genes Cells
Our study shows that m6A regulation is critical for controlling HTLV‐1, shaping both viral transcripts and host gene programs, thereby illuminating latency mechanisms and suggesting tractable targets for therapy and prevention. ABSTRACT Human T‐cell Leukemia Virus Type 1 (HTLV‐1) is a pathogenic human retrovirus that is responsible for intractable ...
Gibu R, Gibu K, Suzuki K, Tanaka Y, Uchimaru K, Yamagishi M.   +5 more
europepmc   +2 more sources

Single-Crystal-to-Single-Crystal Transformation in a Copper(II) Complex: Structural and Spectroscopic Insights into Methanol Elimination and Hydrogen Bond Network Formation. [PDF]

ChemistryOpen
A methanol‐ligated copper(II) complex undergoes a single‐crystal‐to‐single‐crystal transformation upon solvent loss, retaining crystallinity while reorganizing its coordination geometry and hydrogen‐bonding network. This study investigates the single‐crystal‐to‐single‐crystal (SCSC) transformations of a copper(II) complex, [Cu(L1)2(acac)2]·2CH3OH (1 ...
Mirtamizdoust B, Karamad A, Mojtabazade F, Hosseini-Monfared H, Bikas R.   +4 more
europepmc   +2 more sources

Mortality from cancer and non-cancer diseases in the Lithuanian cohort of Chernobyl cleanup workers (2001-2020). [PDF]

Int J Cancer
What's new? Following the Chernobyl disaster, workers were recruited from formerly Soviet‐occupied areas, including Lithuania, to participate in clean‐up efforts. Radiation exposure incurred by workers during these efforts offers a unique opportunity for the study of long‐term health effects.
Steponaviciene R, Kesminiene A, Kaceniene A, Smailyte G.   +3 more
europepmc   +2 more sources