Results 31 to 40 of about 24,050,334 (247)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Functional activities of C-reactive protein on neutrophils [PDF]

C-reactive protein (CRP) is a member of the pentraxin family which opsonises S. pneumoniae through its binding to phosphorylcholine. In addition, CRP binds to Fcγ receptors: FcγRI with high affinity and, probably, FcγRIIA with lower affinity.
Rodriguez, Jairo Antonio
core   +1 more source

C-Reactive Protein [PDF]

Circulation Research, 2014
C-Reactive protein (CRP) is a member of the pentraxin family of proteins and is highly conserved throughout evolution. In humans, CRP is a major acute phase protein with well-defined roles in innate and adaptive immunity.1 CRP expression is induced by inflammatory cytokines; primarily interleukin-6 (IL-6) with other factors, including IL-1β and tumor ...
Nancy S, Jenny, Mary, Cushman
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

C-reactive protein and nutrition

Bratislava Medical Journal, 2005
High sensitivity C-reactive protein (hsCRP) is a proven method to better predict the cardiovascular risk and target therapeutic interventions. Serum concentrations of hsCRP were measured in an adult apparently healthy population aged 19-75 years of different nutrition: a vegetarian group (lacto- and lacto-ovo-vegetarians who consumed plant food, dairy ...
M, Krajcovicova-Kudlackova, P, Blazicek
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

C-Reactive protein and genetic variants and cognitive decline in old age: the PROSPER Study [PDF]

, 2011
Background: Plasma concentrations of C-reactive protein (CRP), a marker of chronic inflammation, have been associated with cognitive impairment in old age. However, it is unknown whether CRP is causally linked to cognitive decline.
van Himbergen Thomas, Rudi G. J. Westendorp, Eliana Polisecki, Trompet, S., Sattar, N., David J. Stott, Ian Ford, Ford Ian, Ford, I., Trompet Stella, Simon P. Mooijaart, David J Stott, Sattar Naveed, Welsh Paul, Himbergen, T. van, Jahn Sabine E., Westendorp Rudi G. J., Jahn, S.E., Paul Welsh, Mooijaart, S.P., Ernst J Schaefer, Schaefer, E.J., Welsh, P., Westendorp, R.G.J., Anton J. M. de Craen, Stott David J., Sabine E. Jahn, Mooijaart Simon P., Craen, A.J.M. de, de Craen, A.J.M., Thomas van Himbergen, Ernst J. Schaefer, Stella Trompet, Polisecki Eliana, Sabine E Jahn, Anton J M de Craen, de Craen Anton J. M., Naveed Sattar, Polisecki, E., van Himbergen, T., null null, Simon P Mooijaart, PROSPER Study Group, PROSPER Study Grp, Stott, D.J., Rudi G J Westendorp, Schaefer Ernst J.   +46 more
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability [PDF]

, 2005
Background - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated.
Stidwill, RP, Singer, M, MacAllister, RJ, Storry, C, Pepys, MB, Vallance, P, Deanfield, JE, Hineorani, AD, Clapp, BR, Hirschfield, GM, Gallimore, JR   +10 more
core