Results 101 to 110 of about 41,423,067 (260)
Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales +11 morewiley +1 more sourceMeasurement of the lifetime of the B-c(+) meson using the B-c(+) -> J/psi pi(+) decay mode
, 2015 The difference in total widths between the B-c(+) and B+ mesons is measured using a data sample corresponding to an integrated luminosity of 3.0 fb(-1) collected by the LHCb experiment in 7 and 8 TeV centre-of-mass energy proton-proton collisions at the ...Hennessy K., Parkinson C. J., Blouw J., Nasteva I., Aquines Gutierrez O., Ben-Haim E., Han X., Li Y., Dosil Suarez A., Charpentier P., Bizzeti A., Brook N. H., Eklund L., Garcia Pardinas J., Jalocha J., Akar S., Cid Vidal X., Bjornstad P. M., Borsato M., Dean C. T., Dordei F., Bifani S., Hutchcroft D., Archilli F., Calvo Gomez M., Clemencic M., Chefdeville M., Amhis Y., Carson L., Brodzicka J., Longstaff I., Pinci D., Gastaldi U., Cogneras E., Kanso W., Garcia L. Castillo, Alessio F., Baalouch M., Krokovny P., Artamonov A., Firlej M., Cook A., Kucewicz W., Bursche A., Berezhnoy A., Golutvin A., Neri N., Guz Y.u., Hussain N., Poluektov A., Marino P., Machefert F., Harnew N., Panman J., Klimaszewski K., Pepe Altarelli M., Francisco O., Artuso M., Akiba K. Carvalho, De Silva W., Haefeli G., Giubega L., Cheung S. -F., Coquereau S., Grillo L., Decamp D., Corti G., Garrido L., Gomes A., Cogan J., Owen P., McNab A., Coombes M., Beddow J., Gersabeck E., Filippov S., Kucharczyk M., Minard M. N., Lohn S., Dey B., Bachmann S., Gazzoni G., Davis A., Nakada T., Cauet C., Andrews J. E., Petrolini A., Hill D., Gianiy S., Lindner R., Gavardi L., Affolder A., Fiutowski T., Bonivento W., Falabella A., Dziurda A., Eisenhardt S., Ferro-Luzzi M., Lionetto F., Brett D., Cliff H. V., Goebel C., Gruenberg O., De Bruyn K., Polci F., Dorigo M., Le Gac R., Aaij R., Cadeddu S., David P. N. Y., Hernando Morata J. A., Blake T., Kvaratskheliya T., Evans H. M., Polycarpo E., Chen S., Bettler M. O., Penso G., Muller K., Lowdon P., Onderwater C. J. G., Needham M., Frei C., Fontana M., Krocker G., Blanc F., Ghez P.h., Graverini E., Baesso C., Dalseno J., Britton T., Perret P., Plo Casasus M., Pal B. K., Barter W., Matteuzzi C., Luppi E., Prouve C., Carvalho Akiba K., Calvi M., Frosini M., Pietrzyk B., Esen S., Campana P., Puig Navarro A., Batozskaya V., Deleage N., Lai A., Bowcock T. J. V., Ali S., Britsch M., Navarro A. Puig, Chiapolini N., Ciezarek G., Maciuc F., Minard M. -N., Langenbruch C., Cassina L., Muheim F., Niet R., Ferro Luzzi M., Bertolin A., Martinelli M., Tostes D. Martins, De Ckenhoff M., Cheung S. F., Morawski P., Gys T., Harrison J., Benson S., De Simone P., Garofoli J., Patrignani C., Molina Rodriguez J., Henrard P., Belyaev I., Eidelman S., Idzik M., Novoselov A., Deckenhoff M., Counts I., Anderson J., Pellegrino A., O'Hanlon D. P., Easo S., Nguyen-Mau C., Harnew S. T., Dossett D., Lupton O., De Miranda J. M., Ben Haim E., Gregson S., Gushchin E., Kudryavtsev V., Gersabeck M., Moron J., Lacarrere D., Cardinale R., Dijkstra H., Derkach D., John M., Hamilton B., Jaton P., Borgia A., David P., Johnson D., Liu B., Neubert S., Greening E., Hulsbergen W., Gambetta S., Kruse F., Maratas J., Manca G., Gershon T., Hansmann Menzemer S., Jurik N., Jing F., Bondar N., Lesiak T., Malinin A., Calabrese R., Barschel C., Torres M. Cruz, Gallas Torreira A., Hoballah M., Massafferri A., Grauges E., Collazuol G., Lefevre R., Haen C., Graziani G., Dujany G., Di Domenico A., Lupato A., Comerma Montells A., Farinelli C., Pilar T., Cardoso L. A. Granado, Guz Y., Patel M., Kolpin M., Mueller K., Lambert D., Farber C., Cojocariu L., Heijne V., Petridis K., Blusk S., Ferguson D., Prisciandaro J., Crocombe A. C., Farry S., Obraztsov V., Oblakowska Mucha A., Bettler M. -O., An L., Bernet R., Neufeld N., Meissner M., Henry L., Dean C. -T., Palano A., Carboni G., Donleavy S., Nikodem T., Fu J., Marconi U., Machikhiliyan I. V., van herwijnen E., Gandara M. Grabalosa, Moggi N., Dzyuba A., Nicol M., Cogoni V., Grecu A., Merk M., Cattaneo M., Karbach T. M., Forty R., Mathe Z., Gobel C., Closier J., Naik P., Garra Tico J., Pesen E., Popov D., Orlandea M., Mountain R., Karacson M., Pugatch V., Dupertuis F., Egede U., Gandelman M., Kenyon I. R., Lopes J. H., Palombo F., Bencivenni G., Cauet C.h., Belous K., Dzhelyadin R., Gascon D., Jones C. R., Bondar A., Casanova Mohr R. C. M., Cardini A., Del Buono L., Aslanides E., McNulty R., Milanes D. A., Leverington B., Lazzeroni C., Neuner M., Potterat C., Fernandez Albor V., Durante P., Latham T., Papanestis A., Elsasser C., Muster B., Jawahery A., Currie R., Ogilvy S., Corvo M., Hombach C., Nguyen Mau C., Gutierrez O. Aquines, Dovbnya A., Passaleva G., Liles M., van Leerdam J., Cunliffe S., Karodia S., Craik D. C., Barsuk S., Fiorini M., D'Ambrosio C., Lanfranchi G., Baldini W., Kochebina O., Gibson V., Granado Cardoso L. A., Amerio S., Morris A. -B., Jost B., Mancinelli G., De Cian M., Coco V., Bien A., Oyanguren A., Gui B., Oblakowska-Mucha A., Hicheur A., Khurewathanakul C., Back J. J., Palutan M., Martins Tostes D., Tico J. Garra, Castillo Garcia L., Badalov A., Oldeman R., Otalora Goicochea J. M., Price J. D., Marks J., Marchand J. F., Bocci V., Charpentier P.h., Pescatore L., Gallorini S., Fontanelli F., Maev O., Nguyen T. D., Okhrimenko O., Grunberg O., Griffith P., Komarov I., Head T., OtaloraGoicochea J. M., Cruz Torres M., Perazzini S., Linn C., Capriotti L., Ekelhof R., Koppenburg P., Gao Y., Patel G. D., Playfer S., Clarke P. E. L., El Rifai I., Haines S. C., Farley N., Kreplin K., Popov A., Pappagallo M., Casasus M. Plo, Geraci A., Kravchuk L., Khanji B., Dettori F., Morello M. J., Maerki R., Matev R., Picatoste Olloqui E., Hall S., Mazurov A., Adinolfi M., Faerber C., McCann M., Grabalosa Gandara M., He J., McSkelly B., Altarelli M. Pepe, Couturier B., Gotti C., Giani S., Collins P., Casse G., COGONI, VIOLETTA, Morandin M., Pappalardo L. L., Belogurov S., De Paula L., Campora Perez D., Frank M., Monteil S., Marki R., Luo H., Elsasser C.h., Auriemma G., Mussini M., Hadjivasiliou C., Korolev M., Gaspar C., Niess V., Gianelle A., Bowen E., Egorychev V., Mapelli A., OLDEMAN, RUDOLF GERHARD CHRISTIAAN, Langhans B., Polyakov I., Battista V., Dreimanis K., Martinez Vidal F., De Capua S., Price E., Andreassen R., Adeva B., Kandybei S., Likhomanenko T., Morda A., Andreotti M., Galli D., De Camp D., Buytaert J., Koopman R. F., Meier F., Deschamps O., Ely S., Santos D. Martinez, Graciani Diaz R., Lefrancois J., Nguyen A. D., Cenci R., Otto A., Evans T., Fay R., Pritchard A., Carbone A., Kelsey M., Anderlini L., Gligorov V. V., Eitschberger U., McCarthy J., La Thi V. N., Benton J., Comerma-Montells A., Jans E., Alves A. A. J.r., Chrzaszcz M., Perez D. Campora, Gauld R., Hampson T., Gandini P., Lees J. -P., Albrecht J., Parkes C., Marin Benito C., Barlow R. J., Nikitin N., Lafferty G., Kurek K., Hansmann-Menzemer S., Jaeger A., van Beuzekom M., Martinez Santos D., Bozzi C., Vidal X. Cid, Alves A. A., Fol P., Jacobsson R., Klaver S., Vidal F. Martinez, Alkhazov G., Nandakumar R., Beaucourt L., Bediaga I., Alvarez Cartelle P., Amato S., MANCA, GIULIA, Lucchesi D., Ilten P., Joram C., Hynds D., Alexander M., Charles M., Ghez P., Lees J. P., Leroy O., Rodrigues F. Ferreira, Pearce A., Fitzpatrick C., Bay A., Appleby R. B., Di Canto A., Leflat A., Ferreira Rodrigues F., Borghi S., Cowan G. A., Pistone A., Contu A., Hess M., Lambert R. W., Popovici B., Golubkov D., Ajaltouni Z., Furfaro E., Malde S., Bedeschi F., Kreps M., Ketel T., Martellotti G., Morris A. B., Bird T., Fiore M., Meadows B. +545 morecore +1 more sourceKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceTranscriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel +14 morewiley +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more sourceStimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi +19 morewiley +1 more source
