Results 161 to 170 of about 41,423,067 (260)

Separation, Structural Elucidation, and Anticancer Activity of a Diastereoisomer of Betulonic Acid-Zidovudine Conjugates. [PDF]

ACS Omega
Zhai J, Wang L, Liu M, Wang L, Tang C, Park JH, Qi S, Zhang C, Wang Y, Kang Q, Shin YK, Wang Q.   +11 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

3D ex vivo platform for high-throughput immunotherapy screening in relapsed/refractory lymphoma patients. [PDF]

Hemasphere
Gava F, Marcoux P, Serrat N, Gravelle P, Quertinmont S, Tosolini M, Faria C, Valero JG, Schniederjohann C, Quelen C, Bouquet F, Fonseca C, Herter S, Deak LC, McCord R, Chiang E, Bruch PM, Ysebaert L, Pérez-Galán P, Laurent C, Bezombes C.   +20 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Unnatural C6-Substituted d-Galactosides as Attenuated Substrates of Glycosyl Hydrolases. [PDF]

Chembiochem
Plodukhin AY, Hernández K, Demirovic S, Ogunmilade T, Mercado BQ, Kennedy M, Angeles-Boza A, Planas A, Peczuh MW.   +8 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Surrogate modeling based on computational fluid dynamics for predicting the capsizing moment in a coupled shiplift system. [PDF]

PLoS One
Tang T, Yang J, Hu Z, You J, Zhang Y, Shi D.   +5 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Mitochondrial haplotypes and microsatellite genotypes for grass and water snakes of the genus <i>Natrix</i>: A range-wide resource (Squamata, Natricidae). [PDF]

Biodivers Data J
Criado-Flórez A, Asztalos M, Kindler C, Neumann A, Schultze N, Fritz U.   +5 more
europepmc   +1 more source