Non-ROS-Mediated Cytotoxicity of ZnO and CuO in ML-1 and CA77 Thyroid Cancer Cell Lines [PDF]
International Journal of Molecular Sciences, 2023 Metal oxide nanoparticles (MONPs) are widely used in agriculture and food development but there is little understanding of how MONPs, including ZnO, CuO, TiO2, and SnO2, impact human health and the environment. Our growth assay revealed that none of these (up to 100 µg/mL) negatively affect viability in the budding yeast, Saccharomyces cerevisiae.
Nakaja Weaver, Kyoungtae Kim
exaly +5 more sources
G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor β2 in the rat hypothalamic paraventricular nucleus. [PDF]
PLoS ONE, 2020 Thyroid hormone (T3) inhibits thyrotropin-releasing hormone (TRH) synthesis in the hypothalamic paraventricular nucleus (PVN). Although the T3 receptor (TR) β2 is known to mediate the negative regulation of the prepro-TRH gene, its molecular mechanism ...
Go Kuroda +13 more
doaj +3 more sources
Impact of Food Components on in Vitro Calcitonin Gene-Related Peptide Secretion—A Potential Mechanism for Dietary Influence on Migraine [PDF]
Nutrients, 2016 Calcitonin gene-related peptide (CGRP) is a pivotal messenger in the inflammatory process in migraine. Limited evidence indicates that diet impacts circulating levels of CGRP, suggesting that certain elements in the diet may influence migraine outcomes ...
Margaret Slavin
exaly +3 more sources
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1 [PDF]
FEBS Letters, Volume 599, Issue 21, Page 3150-3162, November 2025.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +2 more sources
Whole genome sequencing of a clinical drug resistant Candida albicans isolate reveals known and novel mutations in genes involved in resistance acquisition mechanisms. [PDF]
J Med Microbiol, 2021 Candida albicans is an opportunistic pathogen accounting for the majority of cases of Candida infections. Currently, C. albicans are developing resistance towards different classes of antifungal drugs and this has become a global health burden that does ...
Khalaf RA +3 more
europepmc +2 more sources
Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration. [PDF]
Nat Commun, 2022 Gomez-Sintes R +15 more
europepmc +1 more source
Advancing positive social determinants of health through collective impact and the 100% New Mexico Model. [PDF]
Arch Public Health, 2023 McCrae JS, Spain AK.
europepmc +1 more source
Epigenetic Connection of the Calcitonin Gene-Related Peptide and Its Potential in Migraine. [PDF]
Int J Mol Sci, 2022 Fila M +3 more
europepmc +1 more source
Nutrition and Calcitonin Gene Related Peptide (CGRP) in Migraine. [PDF]
Nutrients, 2023 Fila M +4 more
europepmc +1 more source
Incomplete Sterility of Chromosomal Hybrids: Implications for Karyotype Evolution and Homoploid Hybrid Speciation. [PDF]
Front Genet, 2020 Lukhtanov VA +4 more
europepmc +1 more source