Results 111 to 120 of about 8,070,232 (284)

Serum carcinoembryonic antigen tends to decrease in poorly-differentiated colorectal cancer

Universa Medicina, 2015
BACKGROUND Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 are tumor markers for colorectal cancer (CRC), both having prognostic value.
Ester Morina Silalahi, Lukman Hakim Zain, Rustam Effendi   +2 more
doaj   +1 more source

Two Proton Emission in the Hyperspheric Harmonics Approach

, 1999
Nuclear decays into three-particle channels are considered in a few-body approach of hyperspherical harmonics with emphasis on simultaneous, or direct, emission of two protons.
Mukha, Ivan
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Sulphur and zinc abundances in Galactic stars and damped Lyman-alpha systems

, 2003
High resolution spectra of 34 halo population dwarf and subgiant stars have been obtained with VLT/UVES and used to derive sulphur abundances from the 8694.0, 8694.6 A and 9212.9, 9237.5 A SI lines.
Alonso, Alonso, Alonso, Asplund, Asplund, Asplund, Asplund, Biémont, Boissier, Calura, Carigi, Carney, Carpenter, Carretta, Centurión, Centurión, Chen, Chiappini, Dekker, Dekker, Dessauges-Zavadsky, Ellison, Feltzing, François, François, Fuhrmann, Goswami, Gratton, Gratton, Grevesse, Hill, Holweger, Israelian, Jenkins, Kanekar, Kirkman, Kiselman, Kiselman, Lambert, Ledoux, Lopez, Lopez, Lu, M. Asplund, M. Pettini, Matteucci, Mishenina, Mitchell, Mo, Molaro, Nakamura, Nissen, Nissen, Nissen, Norris, P. E. Nissen, Petitjean, Pettini, Pettini, Pettini, Prochaska, Prochaska, Prochaska, Ryan, Ryde, Savage, Schuster, Schuster, Seaton, Shchukina, Shetrone, Sneden, Stephens, Takada-Hidai, Thévenin, Tolstoy, Uitenbroek, VandenBerg, Vladilo, Vladilo, Y. Q. Chen   +80 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Prognostic significance of CA 19-9 [PDF]

HPB, 2021
K. Meredith, J. Huston, R. Shridhar
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source