Results 61 to 70 of about 2,389 (204)

Nanopore Electroporation: A New Delivery Method Within the Field of Epigenetic Editing

open access: yesSmall, EarlyView.
Nanopore‐mediated electroporation was used to deliver a CRISPRi system to clonal β‐cells. This enabled targeted downregulation of insulin expression while maintaining high cell viability. ABSTRACT Epigenetic modifications influence gene expression and contribute to type 2 diabetes (T2D), but establishing causality requires targeted modulation of ...
Frida Ekstrand   +7 more
wiley   +1 more source

(Dis)information Systems: a Systemic View of Disinformation

open access: yesSystems Research and Behavioral Science, EarlyView.
ABSTRACT Disinformation is an ancient social phenomenon that has found a favourable environment for dissemination in internet‐based social networks. While the scientific community seeks to address the problem by creating specific tools to detect and classify the various types of false information, we argue that systems thinking is necessary to ...
Herbert Laroca   +2 more
wiley   +1 more source

Clinical Effect Analysis of Spinal Cord Electrical Stimulator Implantation for Diabetic Foot

open access: yesNeuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective To investigate the clinical effect of spinal cord electrical stimulator implantation in the treatment of diabetic foot (DF). Materials and Methods We recruited 19 patients with DF who were admitted to Shengjing Hospital of China Medical University between January 2018 and May 2020.
Peng‐Bo Zhou, Min Bao
wiley   +1 more source

Split‐disk testing of precast ultra‐high performance fiber‐reinforced concrete tubes

open access: yesStructural Concrete, EarlyView.
Abstract Ultra‐high performance fiber‐reinforced concrete (UHPFRC) has great potential for structural applications involving precast cylindrical shapes, including pipes, silos and stay‐in‐place forms for concrete columns. This study examines the performance of UHPFRC rings under internal pressure simulated using the split‐disk loading method, along ...
Mina Fakeh, Amir Fam
wiley   +1 more source

Evaluation of thyroglobulin autoantibodies in dogs at the time of diagnosis of hypoadrenocorticism and during treatment

open access: yesVeterinary Record, EarlyView.
Abstract Background Autoimmune thyroiditis (AIT) may occur more frequently in dogs with hypoadrenocorticism (HA) than previously recognised. The objective of this study was to determine the presence of thyroglobulin autoantibodies (TgAAs) in dogs with HA.
Christin Emming   +6 more
wiley   +1 more source

From pollen provision to pollinator: Species‐specific sterol assimilation by wild bees in urban landscapes

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Human‐driven landscape change, particularly urbanization, is reshaping pollinator communities, yet the functional traits that mediate species persistence remain poorly understood. Dietary specialization is commonly used to predict species vulnerability.
Yan Yang   +5 more
wiley   +1 more source

The Multilevel Implications of a Sinn Féin Government in Ireland

open access: yesThe Political Quarterly, Volume 96, Issue 1, Page 173-179, January/March 2025.
Abstract The electoral growth of Sinn Féin on both sides of the Irish border has generated much political and academic attention in recent years. The party could form part of the government in Dublin for the first time at the next Irish general election, though that outcome is far from certain.
Conor J. Kelly
wiley   +1 more source

Who Runs for Office? Understanding Candidate Diversity, Safety and Localism in the UK General Election 2024

open access: yesThe Political Quarterly, Volume 96, Issue 1, Page 120-126, January/March 2025.
Abstract A record number of candidates contested parliamentary seats in the 2024 general election in the United Kingdom. This article discusses three key aspects that have garnered attention from both academics and practitioners studying the characteristics, motivations and experiences of candidates: gender representation, security concerns and local ...
Sofia Collignon, Wolfgang Rüdig
wiley   +1 more source

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