Results 171 to 180 of about 58,058 (304)

Des vivants et des morts [Débat]

Archéopages, 2014
Michel Tarpin, Michel Signoli, Catherine Chauveau   +2 more
doaj   +1 more source

A novel anatomy and ultrasound curriculum improves physiatry resident confidence with ultrasound-guided musculoskeletal and spasticity procedures. [PDF]

Can Med Educ J
Peltonen J, Sasson T, Kraushaar J, Shukla K, Singh J, Wunder S.   +5 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Ultrasound guidance aids in determining the success of equine temporomandibular joint arthrocentesis. [PDF]

Front Vet Sci
Lopez DE, Carmalt JL.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Emergency access to the subclavian vessels by non-thoracic surgeons: a cadaver-based learning model for orthopedic trauma surgery. [PDF]

Arch Orthop Trauma Surg
Grechenig P, Gänsslen A, Dauwe J, Wittig U, Sagmeister M, Koutp A, Puchwein P, Sadoghi P, Hohenberger G.   +8 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cadaver Dissections in Medical School Based on Functional Neuroanatomy Improve Results: A Double Blind Prospective Randomized Controlled Study. [PDF]

Adv Med Educ Pract
Ternerot J, Vigren P.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Does the tendon retract in flexor hallucis longus muscle laceration? A cadaveric study. [PDF]

Arch Orthop Trauma Surg
Aydın M, Şahin Y, Yağar H, Çiçek F, Ceranoğlu FG, Mert A, Çınaroğlu S.   +6 more
europepmc   +1 more source