In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Changes in Tarsal Tunnel Volume and Pressure After Minimally Invasive Lateral Sliding Calcaneal Osteotomy: A Cadaveric Study. [PDF]
Warburton C +6 more
europepmc +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Practice Makes Perfect: Using Soft-Embalmed Cadavers as a Teaching Model for Hip Reduction. [PDF]
Nageotte C +6 more
europepmc +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Anterior nerves of the knee (ANK) block: A novel motor sparing fascial plane block for analgesia of the knee: Observational cohort study. [PDF]
Balaban O +4 more
europepmc +1 more source
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Cadaveric Renal Transplantation in Diabetics in the 1980's: with Special Reference to Cyclosporine. [PDF]
Hakala, Thomas B +4 more
core
A Comparison of Two Surgical Treatment Methods for Atlantoaxial Instability in Dogs: Finite Element Analysis and a Canine Cadaver Study. [PDF]
Trębacz P +7 more
europepmc +1 more source

