Results 281 to 290 of about 234,741 (400)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

The Safety of Ultrasound-Guided Needle Approaches for Patellar Tendinopathy: A Theoretical Cadaveric Model. [PDF]

J Funct Morphol Kinesiol
Calderón-Díez L, Belón-Pérez P, Fernández-de-Las-Peñas C, Sánchez-Sánchez JL.   +3 more
europepmc   +1 more source

CONFIRMATION OF THE CRUCIAL ROLE OF THE RECIPIENTʼS MAXIMAL HYDRATION ONEARLY DIURESIS OF THE HUMAN CADAVER RENAL ALLOGRAFT

, 1983
Marianne Carlier, Jean‐Paul Squifflet, Yves Pirson, L Decocq, B Gribomont, Guy P. Alexandre   +5 more
openalex   +1 more source

HLA matching assessed from early graft function. [PDF]

, 1987
Berne, TV, Kahan, BD, Mickey, MR, Salvatierra, O, Starzl, TE, Terasaki, PI   +5 more
core  

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Feasibility of the CT-Image-Guided Colpopexy: A Novel, Needle-Based Sacrospinous Ligament Fixation for Treatment of Vaginal Apical Prolapse. [PDF]

Int Urogynecol J
Choi B, Lee KH, Kim C, Chun H, Bae KT.
europepmc   +1 more source

INFLUENCE OF CADAVER DONOR AGE ON THE SUCCESS OF KIDNEY TRANSPLANTS

, 1981
Joon H. Hong, K Z Shirani, Abdul G. Arshad, Ismail Parsa, Arthur Matas, R J Adamsons, Khalid M.H. Butt   +6 more
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Targeted anterior expansion of the cervical facet joints achieves indirect foraminal decompression and reduces spondylolisthesis via a posterior approach: a cadaveric study. [PDF]

J Orthop Surg Res
Al-Habib A, AlEissa S, Al-Jazaeri A.
europepmc   +1 more source