Results 291 to 300 of about 215,865 (348)

Nuclear deformability depends on H3K9-methylated heterochromatin anchorage to the nuclear periphery in Caenorhabditis elegans. [PDF]

Genetics
Gregory EF, Luxton GWG, Starr DA.
europepmc   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, Volume 24, Issue 8, August 2025.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

<i>Caenorhabditis</i> Intervention Testing Program: all-trans retinoic acid-related compounds tamibarotene and bakuchiol do not extend lifespan in <i>Caenorhabditis</i> nematodes. [PDF]

MicroPubl Biol
Banse SA, Coleman-Hulbert AL, Sedore CA, Johnson E, Lithgow GJ, Driscoll M, Phillips PC.   +6 more
europepmc   +1 more source

Metformin and Dietary Restriction Counteract Aging via Reducing m6A–Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)

Aging Cell, Volume 24, Issue 8, August 2025.
Metformin and dietary restriction modulate m6A to extend lifespan of rotifer, highlighting MTR as a central regulator of aging through methionine metabolism. ABSTRACT Metformin, a medication primarily used to treat diabetes, has gained attentions for its potential antiaging properties.
Yu Zhang, Xiaojie Liu, Hairong Lian, Yanchao Chai, Yang Zhou, Dongqi Kan, Jilong Ren, Cui Han, Jiaxin Yang   +8 more
wiley   +1 more source

Extracellular vesicles aid in the transfer of long-term associative memory between Caenorhabditis elegans

Babu K, Bhar M, Nandi T, Narayanan H, Kishore K.   +4 more
europepmc   +1 more source

CompMap: an allele-specific expression read counter based on competitive mapping. [PDF]

MicroPubl Biol
Sanchez-Ramirez S, Cutter A.
europepmc   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

Aging Cell, Volume 24, Issue 8, August 2025.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan, Hongxia Cai, Fang Ye, Wentao Xu, Zhihang Huang, Jingyuan Zhu, Yiwen Gong, Yutong Li, Anastasia Ngozi Ezemaduka, Shan Gao, Shunqi Liu, Guojun Li, Hao Li, Jing Yang, Junyu Ning, Bo Xian   +15 more
wiley   +1 more source

Robust sex determination in the Caenorhabditis nigoni germ line. [PDF]

Genetics
Harbin JP, Shen Y, Lin SY, Kemper K, Haag ES, Schwarz EM, Ellis RE.   +6 more
europepmc   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Microbial genetic composition regulates host social behavior. [PDF]

Gut Microbes
Bai R, Wang T, Gu R, Cai Y, Chen J, Cai W, Zhou D, Li Y, Luo J, Wang X, Zhu Z.   +10 more
europepmc   +1 more source