Results 151 to 160 of about 190,941 (272)

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Developmental expression of Ap‐Vas proteins in aphids and flies reveals their evolutionary roles in insects

Insect Molecular Biology, EarlyView.
Duplication of vas genes is universally observed in aphids, and phylogenetic analysis indicates that this event predates the divergence of Aphididae and Phylloxeridae. Ap‐vas1 is germline‐specific, whereas Ap‐vas2–4 exhibit somatic expression, indicating functional divergence during aphid embryogenesis.
Gee‐Way Lin, Szu‐Chieh Wang, Charles E. Cook, Ming‐Der Lin, Chun‐che Chang   +4 more
wiley   +1 more source

Advances in high‐resolution cryo‐volume electron microscopy (cvEM) imaging for unicellular and multicellular organisms

Journal of Microscopy, EarlyView.
Abstract Cryo‐Focused Ion Beam Scanning Electron Microscopy (cryoFIB‐SEM) using samples fixed by high‐pressure freezing uniquely enables high‐resolution cryo‐volume Electron Microscope (cvEM) images of cell ultrastructure to be obtained from whole cells and complex tissues in their near native state. As the freezing process also preserves fluorescence,
Maryna Kobylynska, Daniel Nicholls, Zoe Broad, Jack Wells, Alex Robinson, Stefania Marcotti, Damien McGrouther, Ch'ng Q‐L, Genoveva Esteban, Nigel Browning, Roland Fleck   +10 more
wiley   +1 more source

Microinjection of Synthetic Peptides Into <i>Caenorhabditis elegans</i>. [PDF]

Bio Protoc
Ohno H, Ida T, Iino Y.
europepmc   +1 more source

Agnosticism about artificial consciousness

Mind &Language, EarlyView.
Could an AI have conscious experiences? Answers to this question should be based not on intuition, dogma or speculation but on solid scientific evidence. However, I argue such evidence is hard to come by and that the only justifiable stance is agnosticism.
Tom McClelland
wiley   +1 more source

Sex Alters Hypoxic Responses in <i>Caenorhabditis elegans</i>. [PDF]

MicroPubl Biol
Bischer AP, Neyland KE, Ahmed Selim N, Wojtovich AP.   +3 more
europepmc   +1 more source

Developing a Robust Multiround HCR-FISH Method Modified for Caenorhabditis elegans. [PDF]

Genes Cells
Yang X, Zeng J, Chen CK, Iino Y, Toyoshima Y.   +4 more
europepmc   +1 more source

Exploring natural sunscreens: UVB protection and antioxidant properties in gadusol‐rich fish roes extracts

Photochemistry and Photobiology, EarlyView.
Gadusol‐rich extracts provide effective UVB protection and antioxidant activity in HaCaT cells and C. elegans, highlighting their potential as natural photochemoprotective agents for pharmaceutical and cosmetic applications. It also demonstrates remarkable in vitro antioxidant capacity and thermal stability over time.
Rocío Isla Naveira, Gabriela Hollmann, José María Monserrat, Ana Paula S. Votto, Julie Medeiros da Silveira, Andressa Mai Matsumoto, Lais Zortéa, Andy Joel Taipe Huisa, Agueda E. Massa, M. Sandra Churio   +9 more
wiley   +1 more source

Computational protocol for quantifying body-bending amplitude and period in Caenorhabditis elegans. [PDF]

STAR Protoc
Shi R, Sun Y, Xiao J, Di Z, Liu H.
europepmc   +1 more source