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Immunity in Caenorhabditis elegans
Current Opinion in Immunology, 2004Until very recently it was not known whether the invertebrate Caenorhabditis elegans was capable of mounting a specific immune response to protect itself from pathogens. It has only just become clear that this simple nematode in fact possesses a complex innate immune system, involving multiple signalling pathways and an armoury of antimicrobial ...
Anne Millet, Jonathan J. Ewbank
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Paramyosin of Caenorhabditis elegans
Journal of Molecular Biology, 1974Abstract Paramyosin has been isolated from the nematode, Caenorhabditis elegans . Its identity has been established by a variety of criteria, including purification, molecular weight, immunological cross reactivity with known paramyosin and formation of characteristic paracrystals.
Henry F. Epstein +3 more
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Optogenetics in Caenorhabditis elegans
2015With a compact neural circuit consisting of entirely mapped 302 neurons, Caenorhabditis elegans plays an important role in the development and application of optogenetics. Optogenetics in C. elegans offers the opportunity that drastically changes experimental designs with increasing accessibility for neural activity and various cellular processes ...
Ikue Mori, Yuki Tsukada
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Transgenesis in Caenorhabditis elegans
2009Two efficient strategies have been developed and are widely used for the genetic transformation of the nematode Caenorhabditis elegans, DNA microinjection, and DNA-coated microparticle bombardment. Both methodologies facilitate the delivery of exogenous DNA into the developing oocytes of adult hermaphrodite animals, which then generate transgenic worms
Nikos Kourtis +3 more
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The kinetochores of Caenorhabditis elegans
Chromosoma, 1982Light microscopy of the mitotic chromosomes of Caenorhabditis elegans suggests that non-localized kinetochores are present, since the chromosomes appear as stiff rods 1 to 2 micrometers in length and lack any visible constriction. The holokinetic structure was confirmed by reconstructions of electron micrographs of dividing nuclei in serially sectioned
J. Nichol Thomson +2 more
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The microRNAs of Caenorhabditis elegans
Seminars in Cell & Developmental Biology, 2010The soil nematode, Caenorhabditis elegans, occupies a central place in the short history of microRNA (miRNA) research. The converse is also true: miRNAs have emerged as key regulatory components in the life cycle of the worm, as well as numerous other organisms.
Eric A. Miska +2 more
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Working with Worms: Caenorhabditis elegans as a Model Organism
Current Protocols Essential Laboratory Techniques, 2019Since its introduction as a laboratory organism 50 years ago, the nematode worm Caenorhabditis elegans has become one of the most widely used and versatile models for nearly all aspects of biological and genomic research. Many experiments in C.
P. Meneely +2 more
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The Caenorhabditis elegans lipidome
Archives of Biochemistry and Biophysics, 2016Lipids play important roles in biology, ranging from building blocks of membranes to signaling lipids. The nematode and model organism Caenorhabditis elegans has been used to explore lipid metabolism and several techniques for their analysis have been employed.
Michael Witting +1 more
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Annual Review of Food Science and Technology, 2018
Caenorhabditis elegans is a small free-living nematode that lives in temperate soil environments. It has been widely employed as an animal model in research involving obesity, aging, and neurodegenerative diseases, including Alzheimer's disease, because ...
Peiyi Shen +3 more
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Caenorhabditis elegans is a small free-living nematode that lives in temperate soil environments. It has been widely employed as an animal model in research involving obesity, aging, and neurodegenerative diseases, including Alzheimer's disease, because ...
Peiyi Shen +3 more
semanticscholar +1 more source
Caenorhabditis elegans development
Current Opinion in Cell Biology, 1989Developmental studies continue to be the primary focus of research on the nematode Caenorhabditis elegang and, as in the past, genetic analysis has been the principle tool for dissecting developmental phenomena. Major advances in the study of early embryogenesis, sex determination, cell lineages and cellular differentiation have resulted from the ...
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