Results 11 to 20 of about 204,221 (349)
Canadian Journal of Gastroenterology, 2004 Some exciting developments and changes have occurred since the May report from the Canadian Association of Gastroenterology (CAG) Research Committee, which I am pleased to share with you.
Derek McKay
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In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats [PDF]
International Journal of Molecular Sciences, 2015 Polyglutamine diseases, including Huntington’s disease and a number of spinocerebellar ataxias, are caused by expanded CAG repeats that are located in translated sequences of individual, functionally-unrelated genes. Only mutant proteins containing polyglutamine expansions have long been thought to be pathogenic, but recent evidence has implicated ...
Grzegorz Figura +2 more
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The number of androgen receptor CAG repeats and mortality in men
The Aging Male, 2022 Introduction The androgen receptor (AR) mediates peripheral effects of testosterone. Evidence suggests that the number of CAG repeats in exon-1 of the AR gene negatively correlates with AR transcriptional activity.
Adrian Heald +8 more
doaj +1 more source
bioRxiv, 2023 Brain region-specific degeneration and somatic expansions of the mutant Huntingtin (mHTT) CAG tract are key features of Huntington’s disease (HD). However, the relationships between CAG expansions, death of specific cell types, and molecular events ...
K. Mätlik +10 more
semanticscholar +1 more source
Nature Neuroscience, 2022 The age at onset of motor symptoms in Huntington’s disease (HD) is driven by HTT CAG repeat length but modified by other genes. In this study, we used exome sequencing of 683 patients with HD with extremes of onset or phenotype relative to CAG length to ...
Branduff McAllister +31 more
semanticscholar +1 more source
CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO-TA-Induced Cardiac Senescence via Mitophagy Defect and cGAS-STING Activation: In Vitro Amelioration by Cycloastragenol. [PDF]
Adv Sci (Weinh)The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Li NW +6 more
europepmc +2 more sources
Neuron, 2022 SUMMARY In Huntington’s disease (HD), the uninterrupted CAG repeat length, but not the polyglutamine length, predicts disease onset. However, the underlying pathobiology remains unclear. Here, we developed bacterial artificial chromosome (BAC) transgenic
Xiaofeng Gu +20 more
semanticscholar +1 more source
Canadian Journal of Gastroenterology, 2000 NEW CAG EXECUTIVE DIRECTOR It is with great pleasure that we announce the appointment of Paul Sinclair MSc as the new executive director of the Canadian Association of Gastroenterology (CAG). Paul started in this position on July 1, 2000. Many members of CAG will be familiar with Paul from his previous position as the principal gastrointestinal ...
openaire +5 more sources
Evaluation of circulating antigen in urine technique for diagnosis of Schistosoma haematobium infection [PDF]
Journal of Bioscience and Applied Research, 2018 Background: Diagnosis of urinary and intestinal schistosomiasis by detecting circulating Schistosome antigens in serum and urine have been developed and assessed to dissolve problems with parasitological diagnosis in low endemic areas or for early ...
Ahmed Yameny
doaj +1 more source
Cell Reports, 2021 Summary CAG repeat expansion in the HTT gene drives Huntington’s disease (HD) pathogenesis and is modulated by DNA damage repair pathways. In this context, the interaction between FAN1, a DNA-structure-specific nuclease, and MLH1, member of the DNA ...
R. Goold +14 more
semanticscholar +1 more source