Results 81 to 90 of about 992,908 (347)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Prospects of developing cage and pen culture in Sudan [PDF]

, 1979
This paper describes the prospects of cage and pen culture in Sudan and recommends that a project for developing pen and cage culture techniques be started for marine and freshwater ...
George, Thomas T.
core   +1 more source

Statistical Physics of Structural Glasses

, 2000
This paper gives an introduction and brief overview of some of our recent work on the equilibrium thermodynamics of glasses. We have focused onto first principle computations in simple fragile glasses, starting from the two body interatomic potential.
, , , , , , , , , , Adams G, Angelani L, Angell C A, Barrat J-L, Bouchaud J-P, Büchner S, Cardenas M, Cavagna A, Chandra P, Coluzzi B, Coluzzi B, Coluzzi B, Crisanti A, De Benedetti P, Franz S, Franz S, Franz S, Gibbs J H, Giorgio Parisi, Goldbart P M, Goldstein M, Hansen J-P, Jäckle J, Kauzman A W, Kirkpatrick T R, Kob W, Marc Mézard, Marinari E, Marinari E, Marinari E, Mézard M, Mézard M, Parisi G, Sciortino F, Sciortino F, Sciortino F, Speedy R J, Stillinger F H   +47 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Cage Encapsulated Gold Nanoparticles as Heterogeneous Photocatalyst for Facile and Selective Reduction of Nitroarenes to Azo Compounds.

Journal of the American Chemical Society, 2018
A discrete nanoscopic organic cage (OC1R) has been synthesized from a phenothiazine based trialdehyde treating with chiral 1,2-cyclohexanediamine building block via dynamic imine bond formation followed by reductive amination.
Bijnaneswar Mondal, P. Mukherjee
semanticscholar   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effect of Housing System, Slaughter Age and Sex on Slaughter and Carcass Parameters of Broiler Ducks

Scientific Papers Animal Science and Biotechnologies, 2023
The aim of this study was to determine the effects of housing system slaughter age and sex on performance and carcass parameters of broiler ducks. The experiment was carried out in half-operation conditions experimental base of Department of Poultry ...
Cyril Hrnčár, Ján Weis, Ľuboslava Petričová, Jozef Bujko   +3 more
doaj  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Reversible chromism of spiropyran in the cavity of a flexible coordination cage

Nature Communications, 2018
Confining molecules to volumes only slightly larger than the molecules themselves can profoundly alter their properties. Molecular switches—entities that can be toggled between two or more forms upon exposure to an external stimulus—often require ...
D. Samanta, D. Galaktionova, Julius Gemen, L. Shimon, Y. Diskin‐Posner, L. Avram, P. Král, Rafal Klajn   +7 more
semanticscholar   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source